2. Academic Validation
  3. A silk fibroin based bioadhesive with synergistic photothermal-reinforced antibacterial activity

A silk fibroin based bioadhesive with synergistic photothermal-reinforced antibacterial activity

  • Int J Biol Macromol. 2022 Jun 1;209(Pt A):608-617. doi: 10.1016/j.ijbiomac.2022.03.136.
Xiang Ke 1,  Shuxian Tang 1,  Zhiyun Dong 1,  Hao Wang 1,  Xinyuan Xu 1,  Rongmin Qiu 2,  Jiaojiao Yang 3,  Jun Luo 4,  Jianshu Li 5
Affiliations

Affiliations

  • 1 College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610065, China.
  • 2 College & Hospital of Stomatology, Guangxi Medical University, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Health Commission Key Laboratory of Prevention and Treatment for Oral Infectious Diseases, Nanning 530021, China.
  • 3 College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610065, China.; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610065, China.. Electronic address: jiaojiao.yang@scu.edu.cn.
  • 4 College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610065, China.. Electronic address: luojuncd@scu.edu.cn.
  • 5 College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610065, China.; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610065, China.; Med-X Center for Materials, Sichuan University, Chengdu 610041, China.
PMID: 35367271 DOI: 10.1016/j.ijbiomac.2022.03.136
Abstract

Bioadhesives have gained considerable popularity for application in wound closure. However, applying bioadhesives incurs risks associated with Bacterial infection during wound healing. Hence, in this study, a silk fibroin based bioadhesive was constructed via employing natural macromolecule, silk fibroin (SF), to spontaneously coassemble with natural plant polyphenol, tannic acid (TA), and iron oxide nanoparticles (Fe3O4 NPs). In the system, the natural macromolecule SF plays a key role in fabricating the macromolecular network matrix due to the change of the secondary structure of SF (from random coil to β-sheet) under the trigger of TA. Importantly, the strong hydrogen bonding interactions between SF and TA, and the coordination bonds between TA and Fe3O4 NPs endow the bioadhesive with high extensibility, self-healing properties, and considerable wet adhesion. Meanwhile, the synergy between the inherent photothermal properties of Fe3O4 NPs and TA/Fe3+ complexes under near-infrared (NIR) radiation enables the bioadhesive superior photothermal-reinforced Antibacterial activity. The multifunctional natural macromolecule bioadhesive is a potential candidate in clinical wound management for improved outcomes, especially in infected wounds.

Keywords

Bioadhesive; Natural macromolecule; Photothermal antibacterial; Silk fibroin.

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