2. Academic Validation
  3. Downregulation of SHMT2 promotes the prostate cancer proliferation and metastasis by inducing epithelial-mesenchymal transition

Downregulation of SHMT2 promotes the prostate cancer proliferation and metastasis by inducing epithelial-mesenchymal transition

  • Exp Cell Res. 2022 Jun 15;415(2):113138. doi: 10.1016/j.yexcr.2022.113138.
Lei Chen 1,  Hailong Liu 2,  Yiyi Ji 1,  Zehua Ma 1,  Kai Shen 1,  Xun Shangguan 2,  Hongyang Qian 1,  Yu Zhao 3,  Chun-Wu Pan 4,  Wei Xue 5
Affiliations

Affiliations

  • 1 Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • 2 Department of Urology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • 3 Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China. Electronic address: zhaoyu@irm-cams.ac.cn.
  • 4 Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: panchunwu@renji.com.
  • 5 Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: xuewei@renji.com.
PMID: 35398308 DOI: 10.1016/j.yexcr.2022.113138
Abstract

Serine hydroxymethyltransferase 2 (SHMT2) is a key Enzyme that regulates serine/glycine transition; however, its specific function and molecular mechanisms in tumors remain controversial. In this study, we aimed to enhance the understanding in this regard. Through in vitro and in vivo experiments, as well as data analyses using public databases, we investigated the effect of SHMT2 in prostate Cancer. Our results indicated that SHMT2 acts as a prostate Cancer tumor proliferation suppressor and negatively regulates the aggressive behavior of prostate Cancer through activation of epithelial-mesenchymal transition. Additionally, downregulated SHMT2 expression was observed in more advanced prostate Cancer phenotypes, and further analysis showed that its depletion promoted proliferation and migration in prostate Cancer cell lines. Taken together, our results revealed the function of SHMT2 in prostate Cancer and may potentially play a role in the exploration of new therapeutic strategies.

Keywords

EMT; Metastasis; Progression; Proliferation; Prostate cancer; SHMT2.

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