2. Academic Validation
  3. Spiral molecules with antimalarial activities: A review

Spiral molecules with antimalarial activities: A review

  • Eur J Med Chem. 2022 Jul 5:237:114361. doi: 10.1016/j.ejmech.2022.114361.
Jing Yang 1,  Yonggang Wang 1,  Wen Guan 2,  Weiwei Su 1,  Gang Li 2,  Suode Zhang 2,  Hongliang Yao 3
Affiliations

Affiliations

  • 1 Guangdong Engineering & Technology Research Center for Quality and Efficacy Reevaluation of Post-Market Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, 510275, China.
  • 2 Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, Guangdong, 510260, China.
  • 3 Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, Guangdong, 510260, China. Electronic address: yaohl@giz.gd.cn.
PMID: 35461019 DOI: 10.1016/j.ejmech.2022.114361
Abstract

Malaria is a prevalent fatal disease in tropical and subtropical regions around the world. Combinations of Artemisinin, folate antagonists, quinolines, and Antibiotics are major choices in clinics. Currently, wide range of parasite's resistance necessitates the search for chemical compounds with new structures and novel antimalarial targets. The literature review was performed covering the relevant literatures published from 1966 to 2021. On the basis of structural classification (spiro-peroxides, spiroindolones, spirocyclohexadienones et al.), different types of molecules were summarized with resources, anti-malarial activities, structure-activity relationship, target introductions, resistance, development progress, and synthetic strategies, for the purpose of providing comprehensive information for developing antimalarial drugs to overcome drug resistance and highlighting the importance of the spiral structure in medicinal chemistry.

Keywords

Antimalarial; Drug resistance; Spiro; Spiro-peroxides; Spirocyclohexadienones; Spiroindolones; Structure-activity relationship; Synthesis.

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