2. Academic Validation
  3. Occurrence, synthesis and biological activity of 2-(2-phenyethyl)chromones

Occurrence, synthesis and biological activity of 2-(2-phenyethyl)chromones

  • Eur J Med Chem. 2022 Jul 5:237:114397. doi: 10.1016/j.ejmech.2022.114397.
Meiyan Fan 1,  Wei Yang 1,  Min He 1,  Yongjun Li 2,  Zhiyun Peng 3,  Guangcheng Wang 4
Affiliations

Affiliations

  • 1 State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, China; Teaching and Research Section of Natural Medicinal Chemistry, School of Pharmacy, Guizhou Medical University, Guiyang, China.
  • 2 Engineering Research Center for the Development and Application of Ethnic Medicine and TCM Ministry of Education, Guizhou Medical University, Guiyang, China.
  • 3 Office of Drug Clinical Trial Institutions, The Affiliated Hospital of Guizhou Medical University, Guiyang, China. Electronic address: pengzhiyun1986@163.com.
  • 4 State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, China. Electronic address: wanggch123@163.com.
PMID: 35472851 DOI: 10.1016/j.ejmech.2022.114397
Abstract

2-(2-Phenylethyl)chromones (PECs) are a group of naturally occurring compounds, which are characterized as phenylethyl substituent at the C2 position of chromone. They have been isolated mainly from Aquilaria sinensis (Lour.) Gilg. This type of natural compound is correlative with anti-diabetes, Anticancer, antioxidant, Antibacterial, Anticancer, and anti-inflammatory activities. Due to the versatile activities of PECs, more and more researchers use different improved methods to synthesize them and their derivatives. This review mainly focuses on the natural occurrence, chemical synthesis, and biological activities of PECs, which were published up until 2020.

Keywords

2-(2-Phenylethyl)chromone; Biological activities; Occurrence; Synthesis.

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