2. Academic Validation
  3. Phenethoxy Derivatives with Anti-inflammatory Activities from the Betelnut Endophytic Trichoderma asperellum G10

Phenethoxy Derivatives with Anti-inflammatory Activities from the Betelnut Endophytic Trichoderma asperellum G10

  • J Nat Prod. 2022 May 27;85(5):1193-1200. doi: 10.1021/acs.jnatprod.1c00813.
Ming-Yang Chen 1,  Fan-Dong Kong 2,  Li Yang 3,  Qing-Yun Ma 3,  Qing-Yi Xie 3,  Jing Yu 1,  Peng-Wei Chen 3,  Li-Man Zhou 2,  You-Gen Wu 1,  Hao-Fu Dai 3,  You-Xing Zhao 3
Affiliations

Affiliations

  • 1 College of Horticulture, Hainan University, Haikou 570228, People's Republic of China.
  • 2 Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning 530006, People's Republic of China.
  • 3 Hainan Institute for Tropical Agricultural Resources, Haikou Key Laboratory for Research and Utilization of Tropical Natural Products, Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou 571101, People's Republic of China.
PMID: 35512012 DOI: 10.1021/acs.jnatprod.1c00813
Abstract

Eight new phenethoxy derivatives, trichoasperellins A-H (1-8), were isolated from the endophytic fungus Trichoderma asperellum G10 isolated from the medicinal plant Areca catechu L. The structures of these compounds were elucidated from spectroscopic data, J-based configurational analysis, and Mosher's methods. Compounds 1-4 and 6-8 bear one or two multioxidized C7 moieties with the same carbon skeleton. The carbon skeletons of compounds 6-8 are new, all containing three moieties connected via two acetal carbons similar to those of disaccharide glycosides. Compound 4 inhibited nitric oxide production with an IC50 value of 48.3 μM, comparable to that of the positive control indomethacin (IC50, 42.3 μM).

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