2. Academic Validation
  3. Sattahipmycin, a Hexacyclic Xanthone Produced by a Marine-Derived Streptomyces

Sattahipmycin, a Hexacyclic Xanthone Produced by a Marine-Derived Streptomyces

  • J Nat Prod. 2022 May 27;85(5):1211-1217. doi: 10.1021/acs.jnatprod.1c00870.
Kantinan Leetanasaksakul 1 2,  Wilaiwan Koomsiri 1 2,  Takuya Suga 3,  Hirotaka Matsuo 3,  Rei Hokari 3,  Pakorn Wattana-Amorn 4,  Yo Ko Takahashi 3,  Kazuro Shiomi 3 5,  Takuji Nakashima 3 5,  Yuki Inahashi 3,  Arinthip Thamchaipenet 1 2
Affiliations

Affiliations

  • 1 Department of Genetics, Faculty of Science, Kasetsart University, Chatuchak, Bangkok 10900, Thailand.
  • 2 Omics Center for Agriculture, Bioresources, Food and Health, Kasetsart University (OmiKU), Bangkok 10900, Thailand.
  • 3 Kitasato Institute for Life Sciences (Present: O̅mura Satoshi Memorial Institute), Kitasato University, Tokyo 108-8641, Japan.
  • 4 Department of Chemistry, Special Research Unit for Advanced Magnetic Resonance and Center of Excellence for Innovation in Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.
  • 5 Graduate School of Infection Control Sciences, Kitasato University, Tokyo 108-8641, Japan.
PMID: 35512262 DOI: 10.1021/acs.jnatprod.1c00870
Abstract

Sattahipmycin was isolated from the mycelium of marine-derived Streptomyces sp. GKU 257-1 by following the antibiofilm activity against E. coli NBRC 3972 throughout the purification steps. The structure of sattahipmycin was determined to be a new polycyclic xanthone related to xantholipin but lacking a dioxymethylene and a chlorinated carbon. This compound showed activity toward Gram-positive bacteria and Plasmodium falciparum, antibiofilm formation of Escherichia coli, and cytotoxicity to human Cancer cell lines. Using genome sequence data, a biosynthetic pathway leading to sattahipmycin has been proposed involving an uncharacterized type II polyketide synthase biosynthetic gene cluster.

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