2. Academic Validation
  3. Alpinetin: a Dietary Flavonoid with Diverse Anticancer Effects

Alpinetin: a Dietary Flavonoid with Diverse Anticancer Effects

  • Appl Biochem Biotechnol. 2022 Sep;194(9):4220-4243. doi: 10.1007/s12010-022-03960-2.
Sameena Gul # 1 2,  Muhammad Faisal Maqbool # 2,  Dongying Zheng 3,  Yongming Li 1,  Muhammad Khan 4,  Tonghui Ma 5
Affiliations

Affiliations

  • 1 School of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
  • 2 Institute of Zoology, University of the Punjab, Quaid-E-Azam Campus, Lahore, 54590, Pakistan.
  • 3 Department of Obstetrics and Gynecology, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
  • 4 Institute of Zoology, University of the Punjab, Quaid-E-Azam Campus, Lahore, 54590, Pakistan. khan_zoologist@ymail.com.
  • 5 School of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China. matonghui@njucm.edu.cn.
  • # Contributed equally.
PMID: 35567708 DOI: 10.1007/s12010-022-03960-2
Abstract

Cancer is a global burden and mechanistically complex disease with a plethora of genetic, physiological, metabolic, and environmental alterations. The development of dietary nutraceuticals into Cancer chemotherapeutics has emerged as a new paradigm in Cancer treatment. Alpinetin (ALPI) is a novel flavonoid component of multiple edible and medicinal Plants and possesses a wide range of biological and pharmacological activities including Antibacterial, anti-hemostatic, anti-oxidative, anti-hepatotoxic, stomachic, immunosuppressive, and anti-inflammatory. Recently, ALPI has been reported as a bioactive dietary nutraceutical with promising Anticancer activity in various human cancers through multiple mechanisms. The purpose of this review is to compile the data on natural sources of ALPI, and its Anticancer activity including cellular targets and Anticancer mechanism in various human cancers. Moreover, this review will set the stage for further design and conduct pre-clinical and clinical trials to develop ALPI into a lead structure for oncological therapy.

Keywords

Alpinetin; Anticancer mechanism; Apoptosis; Cell signaling; Chemosensitizer.

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