2. Academic Validation
  3. An SI-traceable reference material for virus-like particles

An SI-traceable reference material for virus-like particles

  • iScience. 2022 Apr 25;25(5):104294. doi: 10.1016/j.isci.2022.104294.
Andrea Briones 1 2,  Gustavo Martos 2,  Magali Bedu 2,  Tiphaine Choteau 2,  Ralf D Josephs 2,  Robert I Wielgosz 2,  Maxim G Ryadnov 1 3
Affiliations

Affiliations

  • 1 National Physical Laboratory, Hampton Road, Teddington TW11 0LW, UK.
  • 2 Bureau International des Poids et Mesures, Pavillon de Breteuil, 92312 Sèvres, France.
  • 3 Department of Physics, King's College London, London WC2R 2LS, UK.
PMID: 35573192 DOI: 10.1016/j.isci.2022.104294
Abstract

A reference material for virus-like particles traceable to the International System of Units (Système International d'Unités - the SI) is reported. The material addresses the need for developing Reference Standards to benchmark virus-like gene delivery systems and help harmonize measurement approaches for characterization and testing. The material is a major component of synthetic polypeptide virus-like particles produced by the state-of-the-art synthetic and analytical chemistry methods used to generate gene delivery systems. The purity profile of the material is evaluated to the highest metrological order demonstrating traceability to the SI. The material adds to the emerging toolkit of Reference Standards for quantitative biology.

Keywords

Analytical chemistry; Bioengineering; Biomaterials; Materials science; Nanotechnology.

Figures
Products