2. Academic Validation
  3. Oral Administration of Omega-3 Fatty Acids Attenuates Lung Injury Caused by PM2.5 Respiratory Inhalation Simply and Feasibly In Vivo

Oral Administration of Omega-3 Fatty Acids Attenuates Lung Injury Caused by PM2.5 Respiratory Inhalation Simply and Feasibly In Vivo

  • Int J Mol Sci. 2022 May 10;23(10):5323. doi: 10.3390/ijms23105323.
Juan Li 1,  Meiru Mao 1,  Jiacheng Li 1,  Ziteng Chen 1,  Ying Ji 2,  Jianglong Kong 1,  Zhijie Wang 1,  Jiaxin Zhang 1,  Yujiao Wang 1,  Wei Liang 1,  Haojun Liang 1,  Linwen Lv 1,  Qiuyang Liu 1,  Ruyu Yan 1,  Hui Yuan 1,  Kui Chen 1,  Yanan Chang 1,  Guogang Chen 3,  Gengmei Xing 1
Affiliations

Affiliations

  • 1 CAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, China.
  • 2 Institute of Textiles and Clothing, Hong Kong Polytechnic University, Hunghom, Kowloon, Hong Kong.
  • 3 College of Food Science, Shihezi University, Shihezi 832000, China.
PMID: 35628131 DOI: 10.3390/ijms23105323
Abstract

For developing an effective interventional approach and treatment modality for PM2.5, the effects of omega-3 fatty acids on alleviating inflammation and attenuating lung injury induced by inhalation exposure of PM2.5 were assessed in murine models. We found that daily oral administration of the active components of omega-3 fatty acids, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) effectively alleviated lung parenchymal lesions, restored normal inflammatory cytokine levels and oxidative stress levels in treating mice exposed to PM2.5 (20 mg/kg) every 3 days for 5 times over a 14-day period. Especially, CT images and the pathological analysis suggested protective effects of DHA and EPA on lung injury. The key molecular mechanism is that DHA and EPA can inhibit the entry and deposition of PM2.5, and block the PM2.5-mediated cytotoxicity, oxidative stress, and inflammation.

Keywords

PM2.5; docosahexaenoic acid; eicosapentaenoic acid; lung injury; omega-3 fatty acids.

Figures
Products