2. Academic Validation
  3. From polyploidy to polyploidy reversal: its role in normal and disease states

From polyploidy to polyploidy reversal: its role in normal and disease states

  • Trends Genet. 2022 Oct;38(10):991-995. doi: 10.1016/j.tig.2022.05.007.
Chen-Shiou Wu 1,  Wen-Hsin Lu 2,  Mien-Chie Hung 3,  Yi-Shuian Huang 4,  Hsu-Wen Chao 5
Affiliations

Affiliations

  • 1 Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
  • 2 Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
  • 3 Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan; Research Center for Cancer Biology, China Medical University, Taichung 40402, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung 40402, Taiwan; New Drug Development Center, China Medical University, Taichung 40402, Taiwan; Department of Biotechnology, Asia University, Taichung 41354, Taiwan. Electronic address: mhung@mail.cmu.edu.tw.
  • 4 Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan. Electronic address: yishuian@ibms.sinica.edu.tw.
  • 5 Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan. Electronic address: chaohw3619@tmu.edu.tw.
PMID: 35637074 DOI: 10.1016/j.tig.2022.05.007
Abstract

Polyploidization and polyploidy reversal (depolyploidization) are crucial pathways to conversely alter genomic contents in organisms. Understanding the mechanisms switching between polyploidization and polyploidy reversal should broaden our knowledge of the generation of pathological polyploidy and pave a new path to prevent related diseases.

Keywords

nuclear budding; nucleophagy; polyploidy; polyploidy reversal; reductive mitosis.

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