2. Academic Validation
  3. Actinoidin A2, a novel glycopeptide: production, preparative HPLC separation and characterization

Actinoidin A2, a novel glycopeptide: production, preparative HPLC separation and characterization

  • J Antibiot (Tokyo). 1987 Feb;40(2):165-72. doi: 10.7164/antibiotics.40.165.
J J Dingerdissen,  R D Sitrin,  P A DePhillips,  A J Giovenella,  S F Grappel,  R J Mehta,  Y K Oh,  C H Pan,  G D Roberts,  M C Shearer
PMID: 3570965 DOI: 10.7164/antibiotics.40.165
Abstract

An unidentified Nocardia sp. (SK&F-AAJ-193) was isolated and found to produce actinoidin A and a novel analog which we have named actinoidin A2. This new Glycopeptide antibiotic differs from actinoidin A by the presence of rhamnose instead of acosamine. This analog was isolated using Dianion HP-20 resin followed by a specific Glycopeptide affinity column (Affigel-10-D-Ala-D-Ala). The purification was accomplished using preparative ion-pairing chromatography. Actinoidin A2 is active against Staphylococcus aureus and coagulase-negative Staphylococci although it is less potent than actinoidin A.

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