2. Academic Validation
  3. High-performance liquid chromatographic determination of nafimidone and its major metabolite nafimidone alcohol in human plasma and urine

High-performance liquid chromatographic determination of nafimidone and its major metabolite nafimidone alcohol in human plasma and urine

  • J Chromatogr. 1987 Mar 6;414(2):389-98. doi: 10.1016/0378-4347(87)80063-4.
S Gunawan,  D M Treiman
PMID: 3571406 DOI: 10.1016/0378-4347(87)80063-4
Abstract

A rapid, sensitive and selective method for the determination in plasma and urine of nafimidone, a new antiepileptic drug, and its major metabolite, nafimidone alcohol, has been developed which uses a high-performance liquid chromatographic system and a fluorescence detector for nafimidone or ultraviolet detector for nafimidone alcohol. The detection limits for nafimidone and nafimidone alcohol are 5.0 and 12.5 ng/ml, respectively.

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