2. Academic Validation
  3. Naringenin: A potential flavonoid phytochemical for cancer therapy

Naringenin: A potential flavonoid phytochemical for cancer therapy

  • Life Sci. 2022 Sep 15:305:120752. doi: 10.1016/j.lfs.2022.120752.
Mahzad Motallebi 1,  Mohammed Bhia 2,  Huda Fatima Rajani 3,  Iman Bhia 4,  Hadi Tabarraei 5,  Niloufar Mohammadkhani 6,  Miguel Pereira-Silva 7,  Maryam Sadat Kasaii 8,  Saeedeh Nouri-Majd 9,  Anna-Lena Mueller 10,  Francisco J B Veiga 11,  Ana Cláudia Paiva-Santos 12,  Mehdi Shakibaei 13
Affiliations

Affiliations

  • 1 Nanomedicine Research Association (NRA), Universal Scientific Education and Research Network (USERN), Tehran 7616911319, Iran; Department of Biology, Yadegar-e-Imam Khomeini Shahr-e-Rey Branch, Islamic Azad University, Tehran 1815163111, Iran.
  • 2 Nanomedicine Research Association (NRA), Universal Scientific Education and Research Network (USERN), Tehran 7616911319, Iran; Student Research Committee, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran 1996835113, Iran.
  • 3 Department of Immunology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E0T5, Canada.
  • 4 Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran.
  • 5 Department of Veterinary Biomedical Science, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon SKS7N 5B4, Canada.
  • 6 Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran.
  • 7 Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal; REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.
  • 8 Department of Nutrition Research, Department of Community Nutrition, National Nutrition and Food Technology Research Institute (WHO Collaborating Center); and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran 1981619573, Iran.
  • 9 Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran 14155-6117, Iran.
  • 10 Musculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Faculty of Medicine, Institute of Anatomy, Ludwig-Maximilian-University Munich, 80336 Munich, Germany.
  • 11 Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal; REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal. Electronic address: fveiga@ci.uc.pt.
  • 12 Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal; REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal. Electronic address: acsantos@ff.uc.pt.
  • 13 Musculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Faculty of Medicine, Institute of Anatomy, Ludwig-Maximilian-University Munich, 80336 Munich, Germany. Electronic address: mehdi.shakibaei@med.uni-muenchen.de.
PMID: 35779626 DOI: 10.1016/j.lfs.2022.120752
Abstract

Naringenin is an important phytochemical which belongs to the flavanone group of Polyphenols, and is found mainly in citrus fruits like grapefruits and Others such as tomatoes and cherries plus medicinal Plants derived food. Available evidence demonstrates that naringenin, as herbal medicine, has important pharmacological properties, including anti-inflammatory, antioxidant, neuroprotective, hepatoprotective, and anti-cancer activities. Collected data from in vitro and in vivo studies show the inactivation of carcinogens after treatment with pure naringenin, naringenin-loaded nanoparticles, and also naringenin in combination with anti-cancer agents in various malignancies, such as colon Cancer, lung neoplasms, breast Cancer, leukemia and lymphoma, pancreatic Cancer, prostate tumors, oral squamous cell carcinoma, liver Cancer, brain tumors, skin Cancer, cervical and ovarian Cancer, bladder neoplasms, gastric Cancer, and osteosarcoma. Naringenin inhibits Cancer progression through multiple mechanisms, like Apoptosis induction, cell cycle arrest, angiogenesis hindrance, and modification of various signaling pathways including Wnt/β-catenin, PI3K/Akt, NF-ĸB, and TGF-β pathways. In this review, we demonstrate that naringenin is a natural product with potential for the treatment of different types of Cancer, whether it is used alone, in combination with Other agents, or in the form of the naringenin-loaded nanocarrier, after proper technological encapsulation.

Keywords

Cancer therapy; Nanomedicine; Naringenin; Phytochemicals; Polyphenols; Tumor.

Figures
Products