Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy

Nat Commun. 2022 Aug 30;13(1):5091. doi: 10.1038/s41467-022-32054-0.

Xiao Wang ^# ¹, Wenjing Sun ^# ² ³, Huifang Shi ¹, Huili Ma ¹, Guowei Niu ¹, Yuxin Li ¹, Jiahuan Zhi ¹, Xiaokang Yao ¹, Zhicheng Song ¹, Lei Chen ², Shi Li ², Guohui Yang ¹, Zixing Zhou ¹, Yixiao He ¹, Shuli Qu ¹, Min Wu ⁴, Zhu Zhao ¹, Chengzhu Yin ¹, Chongyang Lin ¹, Jia Gao ¹, Qiuying Li ¹, Xu Zhen ⁴, Lin Li ¹ ⁵, Xiaoyuan Chen ⁶, Xiaogang Liu ⁷, Zhongfu An ⁸ ⁹, Hongmin Chen ¹⁰, Wei Huang ¹¹ ¹² ¹³

Affiliations

1 Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University, Nanjing, 211800, China.
2 State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
3 ZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou, China.
4 MOE Key Laboratory of High Performance Polymer Materials and Technology, Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, and Jiangsu Key Laboratory for Nanotechnology, Nanjing University, Nanjing, 210093, China.
5 The Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University, Xiamen, 361005, Fujian, China.
6 Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Clinical Imaging Research Centre, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, 117597, Singapore, Singapore.
7 Department of Chemistry, National University of Singapore, 117597, Singapore, Singapore.
8 Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University, Nanjing, 211800, China. iamzfan@njtech.edu.cn.
9 The Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University, Xiamen, 361005, Fujian, China. iamzfan@njtech.edu.cn.
10 State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China. hchen@xmu.edu.cn.
11 Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University, Nanjing, 211800, China. vc@nwpu.edu.cn.
12 The Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University, Xiamen, 361005, Fujian, China. vc@nwpu.edu.cn.
13 Frontiers Science Center for Flexible Electronics, MIIT Key Laboratory of Flexible Electronics, Northwestern Polytechnical University, Xi'an, 710072, China. vc@nwpu.edu.cn.
# Contributed equally.

PMID: 36042210 DOI: 10.1038/s41467-022-32054-0

Abstract

X-ray-induced photodynamic therapy utilizes penetrating X-rays to activate Reactive Oxygen Species in deep tissues for Cancer treatment, which combines the advantages of photodynamic therapy and radiotherapy. Conventional therapy usually requires heavy-metal-containing inorganic scintillators and organic photosensitizers to generate singlet oxygen. Here, we report a more convenient strategy for X-ray-induced photodynamic therapy based on a class of organic phosphorescence nanoscintillators, that act in a dual capacity as scintillators and photosensitizers. The resulting low dose of 0.4 Gy and negligible adverse effects demonstrate the great potential for the treatment of deep tumours. These findings provide an optional route that leverages the optical properties of purely organic scintillators for deep-tissue photodynamic therapy. Furthermore, these organic nanoscintillators offer an opportunity to expand applications in the fields of biomaterials and nanobiotechnology.

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