2. Academic Validation
  3. An ischemia-homing bioengineered nano-scavenger for specifically alleviating multiple pathogeneses in ischemic stroke

An ischemia-homing bioengineered nano-scavenger for specifically alleviating multiple pathogeneses in ischemic stroke

  • J Nanobiotechnology. 2022 Aug 31;20(1):397. doi: 10.1186/s12951-022-01602-7.
Ranran Duan  # 1,  Ke Sun  # 2,  Fang Fang 3,  Ning Wang 4,  Ruya He 5,  Yang Gao 1,  Lijun Jing 1,  Yanfei Li 1,  Zhe Gong 1,  Yaobing Yao 1,  Tingting Luan 1,  Chaopeng Zhang 1,  Jinwei Zhang 1,  Yi Zhao 1,  Haojie Xie 1,  Yongyan Zhou 1,  Junfang Teng 1,  Jinfeng Zhang 6,  Yanjie Jia 7
Affiliations

Affiliations

  • 1 Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
  • 2 Department of Urinary Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. fccsunk@zzu.edu.cn.
  • 3 Key Laboratory of Molecular Medicine and Biotherapy, School of Life Sciences, Beijing Institute of Technology, Beijing, 100811, China.
  • 4 Department of Biochemistry, College of Life Sciences, Shaanxi Normal University, Xi'an, 710062, Shanxi, China.
  • 5 The International Medical Center, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, Henan, China.
  • 6 Key Laboratory of Molecular Medicine and Biotherapy, School of Life Sciences, Beijing Institute of Technology, Beijing, 100811, China. jfzhang@bit.edu.cn.
  • 7 Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. jiayanjie1971@zzu.edu.cn.
  • # Contributed equally.
PMID: 36045405 DOI: 10.1186/s12951-022-01602-7
Abstract

Background: Ischemic stroke is one of the most serious global public health problems. However, the performance of current therapeutic regimens is limited due to their poor target specificity, narrow therapeutic time window, and compromised therapeutic effect. To overcome these barriers, we designed an ischemia-homing bioengineered nano-scavenger by camouflaging a catalase (CAT)-loaded self-assembled tannic acid (TA) nanoparticle with a M2-type microglia membrane (TPC@M2 NPs) for ischemic stroke treatment.

Results: The TPC@M2 NPs can on-demand release TA molecules to chelate excessive Fe2+, while acid-responsively liberating CAT to synergistically scavenge multiple ROS (·OH, ·O2-, and H2O2). Besides, the M2 microglia membrane not only can be served as bioinspired therapeutic agents to repolarize M1 microglia into M2 phenotype but also endows the nano-scavenger with ischemia-homing and BBB-crossing capabilities.

Conclusions: The nano-scavenger for specific clearance of multiple pathogenic elements to alleviate inflammation and protect neurons holds great promise for combating ischemic stroke and other inflammation-related diseases.

Keywords

Iron chelation; Ischemic stroke; Microglia polarization; Nano-scavenger; Neuroprotection; Reactive oxygen species elimination.

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