2. Academic Validation
  3. Echiumin E, an Aryl Dihydronaphthalene Lignan from the Australian Invasive Plant Paterson's Curse (Echium plantagineum)

Echiumin E, an Aryl Dihydronaphthalene Lignan from the Australian Invasive Plant Paterson's Curse (Echium plantagineum)

  • J Nat Prod. 2022 Oct 28;85(10):2474-2479. doi: 10.1021/acs.jnatprod.2c00151.
Ju Jin 1 2,  Darren C Holland 3 4,  Anthony R Carroll 3 4,  Matthew Zunk 1 2
Affiliations

Affiliations

  • 1 School of Pharmacy and Medical Science, Griffith University, Gold Coast Campus, Queensland 4222, Australia.
  • 2 Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, Queensland 4222, Australia.
  • 3 School of Environment and Science, Griffith University, Southport, Queensland 4222, Australia.
  • 4 Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland 4111, Australia.
PMID: 36126331 DOI: 10.1021/acs.jnatprod.2c00151
Abstract

A new aryl dihydronaphthalene lignan, echiumin E (1), and four known compounds, echiumin A, globoidnan A, (-)-rabdosiin, and rosmarinic acid (2-5), were isolated from the Australian invasive plant Echium plantagineum (Paterson's curse) for the first time. Echiumin E (1) was characterized by 1D/2D NMR spectroscopy and MS spectrometry, with its absolute configuration assigned through comparison of experimental and TDDFT-calculated ECD data. Echiumin E (1) along with compounds 3-5 were screened in vitro against three Cancer cell lines (SH-SY5Y, HeLa, and PC-3) and a prostate stromal (normal) cell line (WPMY-1) using a resazurin reduction assay. Echiumin E (1) was found to be active toward HeLa cells (IC50 0.21 μM).

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