2. Academic Validation
  3. A Glance at the Development and Patent Literature of Tecovirimat: The First-in-Class Therapy for Emerging Monkeypox Outbreak

A Glance at the Development and Patent Literature of Tecovirimat: The First-in-Class Therapy for Emerging Monkeypox Outbreak

  • Viruses. 2022 Aug 25;14(9):1870. doi: 10.3390/v14091870.
Mazen Almehmadi 1,  Mamdouh Allahyani 1,  Ahad Amer Alsaiari 1,  Mohammed Kanan Alshammari 2,  Abrar Saleh Alharbi 3,  Khansa Hamza Hussain 4,  Lojain Ibrahim Alsubaihi 5,  Mehnaz Kamal 6,  Shahad Saleh Alotaibi 7,  Atheer Nasser Alotaibi 8,  Afeefah Awaid Aldhafeeri 9,  Mohd Imran 10
Affiliations

Affiliations

  • 1 Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
  • 2 Department of Pharmaceutical Care, Rafha Central Hospital, North Zone, Rafha 76312, Saudi Arabia.
  • 3 Department of Pharmaceutical Sciences, Primary Healthcare Center, Mecca 24341, Saudi Arabia.
  • 4 Department of Cardiac Sciences, College of Medicine, King Saud University, Riyadh 11472, Saudi Arabia.
  • 5 Department of Pharmaceutical Care, Prince Sultan Armed Forces Hospital, Medina 42313, Saudi Arabia.
  • 6 Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
  • 7 College of Pharmacy, Shaqra University, Dawadmi, Riyadh 17649, Saudi Arabia.
  • 8 College of Pharmacy, Shaqra University, Shaqra 11961, Saudi Arabia.
  • 9 Department of Nursing, North Area Armed Forced Hospital, King Khalid Military City, Hafr Al-Batin 31991, Saudi Arabia.
  • 10 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia.
PMID: 36146675 DOI: 10.3390/v14091870
Abstract

Monkeypox disease (MPX) is currently considered a global threat after COVID-19. European Medicines Agency (EMA) approved Tecovirimat in capsule dosage form (200 mg) as the first treatment for MPX in January 2022. This article highlights Tecovirimat's development and patent literature review and is believed to benefit the scientists working on developing MPX treatments. The literature for Tecovirimat was gathered from the website of SIGA Technologies (developer of Tecovirimat), regulatory agencies (EMA, United States Food and Drug Administration (USFDA), and Health Canada), PubMed, and freely accessible clinical/patent databases. Tecovirimat was first recognized as an anti-orthopoxvirus molecule in 2002 and developed by SIGA Technologies. The USFDA and Health Canada have also recently approved Tecovirimat to treat smallpox in 2018 and 2021, respectively. The efficacy of Tecovirimat was verified in infected non-human primates (monkeys) and rabbits under the USFDA's Animal Rule. Most clinical studies have been done on Tecovirimat's safety and pharmacokinetic parameters. The patent literature has revealed inventions related to the capsule, injection, suspension, crystalline forms, amorphous form, and drug combinations (Tecovirimat + cidofovir) and process for preparing Tecovirimat. The authors foresee the off-label use of Tecovirimat in the USA and Canada for MPX and other Orthopoxvirus infections. The authors also trust that there is immense scope for developing new Tecovirimat-based treatments (new drug combinations with Other antivirals) for Orthopoxvirus and Other viral diseases. Drug interaction studies and drug resistance studies on Tecovirimat are also recommended. Tecovirimat is believed to handle the current MPX outbreak and is a new hope of biosecurity against smallpox or orthopoxvirus-related bioterrorism attack.

Keywords

SIGA-246; TPOXX; Tecovirimat; monkeypox; orthopoxvirus; patents.

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