2. Academic Validation
  3. Nickel-Catalyzed Oxidative Carbonylation of Alkylarenes to Arylacetic Acids

Nickel-Catalyzed Oxidative Carbonylation of Alkylarenes to Arylacetic Acids

  • Org Lett. 2022 Nov 4;24(43):7972-7977. doi: 10.1021/acs.orglett.2c03121.
Yongzheng Ding 1,  Renbin Huang 1,  Wei Zhang 2,  Hanmin Huang 1 3
Affiliations

Affiliations

  • 1 Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China.
  • 2 Research Institute of Yanchang Petroleum (Group) Company, Ltd, Xi'an 710075, P. R. China.
  • 3 Center for Excellence in Molecular Synthesis, University of Science and Technology of China, Hefei 230026, P. R. China.
PMID: 36287203 DOI: 10.1021/acs.orglett.2c03121
Abstract

A catalytic system combined with NiBr2 and diphenylphosphine oxide that enabled direct access to the valuable arylacetic acids from inexpensive alkylarenes and H2O via oxidative carbonylation was developed. Alkylarenes with primary and secondary benzylic C-H bonds were compatible with this method. Remarkably, the marketed drugs ibuprofen and diclofenac could be easily obtained by this procedure straightforwardly.

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