2. Academic Validation
  3. New N-oxide alkaloids from the stems of Sinomenium acutum

New N-oxide alkaloids from the stems of Sinomenium acutum

  • Fitoterapia. 2023 Mar;165:105404. doi: 10.1016/j.fitote.2022.105404.
Hui-Ling Zeng 1,  Yu-Xing Cai 1,  Shi-Shu Xu 1,  Si-Fang Wu 1,  Ya-Lin Li 1,  Xin-Lin Chen 1,  Ling-Yi Kong 2,  Jian-Guang Luo 3
Affiliations

Affiliations

  • 1 State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
  • 2 State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China. Electronic address: cpu_lykong@126.com.
  • 3 State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China. Electronic address: luojg@cpu.edu.cn.
PMID: 36572115 DOI: 10.1016/j.fitote.2022.105404
Abstract

Six new Alkaloids (1-6) and six known Alkaloids (7-12) were obtained from the stems of Sinomenium acutum. Among them, compounds 1-3 and 6 were four N-oxide Alkaloids. The structures and absolute configurations of these new Alkaloids were elucidated through comprehensive data of 1D and 2D NMR, HRESIMS and ECD spectra. All isolated compounds were evaluated in vitro for their inhibitory activities against nitric oxide (NO) production and inhibitory effects on AChE. Among them, the sinomenine N-oxide (9) was the most potent NO production inhibitor, with an IC50 value of 23.04 μM.

Keywords

Alkaloids; Menispermaceae; NO production inhibitory activity; Sinomenium acutum.

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