2. Academic Validation
  3. Total Syntheses, Absolute Configurations, and Cytotoxicity Evaluation of Ugonstilbenes A, B, and C from the Rhizomes of Helminthostachys zeylanica

Total Syntheses, Absolute Configurations, and Cytotoxicity Evaluation of Ugonstilbenes A, B, and C from the Rhizomes of Helminthostachys zeylanica

  • J Nat Prod. 2023 Feb 24;86(2):307-316. doi: 10.1021/acs.jnatprod.2c00919.
Cheng-Tin Lin 1,  Yao-Hung Yang 2,  Jing-Jy Cheng 1,  Ming-Jaw Don 1 2
Affiliations

Affiliations

  • 1 National Research Institute of Chinese Medicine, No. 155-1, Sec. 2, Linong Street, Beitou District, Taipei 11221, Taiwan, R.O.C.
  • 2 Department of Chemistry, Chinese Culture University, No. 55, Hwa-Kang Road, Yang-Ming-Shan, Taipei 11114, Taiwan,R.O.C.
PMID: 36691388 DOI: 10.1021/acs.jnatprod.2c00919
Abstract

This study describes the first and efficient syntheses of the naturally occurring ugonstilbenes A, B, and C. The stilbene skeleton was prepared using the Horner-Wadsworth-Emmons reaction. On the basis of their specific rotations, the absolute configurations of ugonstilbenes A and C were both determined to be R, while the absolute configuration of ugonstilbene B was determined as 4aS,9aR. The synthesized compounds showed cytotoxic activities against selected human Cancer cell lines.

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