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  3. An efficient metal-organic framework-based drug delivery platform for synergistic antibacterial activity and osteogenesis

An efficient metal-organic framework-based drug delivery platform for synergistic antibacterial activity and osteogenesis

  • J Colloid Interface Sci. 2023 Mar 2;640:521-539. doi: 10.1016/j.jcis.2023.02.149.
Yunhui Si 1,  Huanyao Liu 2,  Mengsha Li 3,  Xuzhou Jiang 4,  Hongying Yu 5,  Dongbai Sun 6
Affiliations

Affiliations

  • 1 School of Materials, Sun Yat-sen University, Shenzhen, 518107, PR China.
  • 2 Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou 510080, PR China.
  • 3 School of Materials Science and Engineering, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University, Guangzhou, 510006, PR China.
  • 4 School of Materials Science and Engineering, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University, Guangzhou, 510006, PR China; Nanotechnology Research Center, Sun Yat-sen University, Guangzhou 510275, PR China. Electronic address: jiangxzh7@mail.sysu.edu.cn.
  • 5 School of Materials, Sun Yat-sen University, Shenzhen, 518107, PR China. Electronic address: yuhy26@mail.sysu.edu.cn.
  • 6 School of Materials Science and Engineering, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University, Guangzhou, 510006, PR China. Electronic address: sundongbai@mail.sysu.edu.cn.
PMID: 36878070 DOI: 10.1016/j.jcis.2023.02.149
Abstract

Bone implants for clinical application should be endowed with Antibacterial activity, biocompatibility, and even osteogenesis-promoting properties. In this work, metal-organic framework (MOF) based drug delivery platform was used to modify titanium implants for improved clinical applicability. Methyl Vanillate@Zeolitic Imidazolate Framework-8 (MV@ZIF-8) was immobilized on the polydopamine (PDA) modified titanium. The sustainable release of the Zn2+ and MV causes substantial oxidative damage to Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The increased Reactive Oxygen Species (ROS) significantly up-regulates the expression of oxidative stress and DNA damage response genes. Meanwhile, the structural disruption of lipid membranes caused by the ROS, the damage caused by Zinc active sites and the damage accelerated by the MV are both involved in inhibiting Bacterial proliferation. The up-regulated expression of the osteogenic-related genes and proteins indicated that the MV@ZIF-8 could effectively promote the osteogenic differentiation of the human bone mesenchymal stem cells (hBMSCs). RNA Sequencing and Western blotting analysis revealed that the MV@ZIF-8 coating activates the canonical Wnt/β-catenin signaling pathway through the regulation of tumor necrosis factor (TNF) pathway, thereby promoting the osteogenic differentiation of the hBMSCs. This work demonstrates a promising application of the MOF-based drug delivery platform in bone tissue engineering.

Keywords

Antibacterial; Drug delivery; MOF; Osteogenesis; Titanium implants.

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