2. Academic Validation
  3. Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating Nrf2/HO-1 axis

Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating Nrf2/HO-1 axis

  • Int Immunopharmacol. 2023 May:118:110029. doi: 10.1016/j.intimp.2023.110029.
Yuan An 1,  Qiang Luo 2,  Donghai Han 1,  Lianyue Guan 3
Affiliations

Affiliations

  • 1 Department of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
  • 2 Department of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
  • 3 Department of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China. Electronic address: guanly@jlu.edu.cn.
PMID: 36963265 DOI: 10.1016/j.intimp.2023.110029
Abstract

Abietic acid has been known to exhibit anti-inflammatory activity. This study was designed to investigate the protective effects of abietic acid on acetaminophen (APAP)-induced liver injury. The data demonstrated that abietic acid significantly ameliorated APAP-induced liver pathological changes, TNF-α and IL-1β production. APAP could increase malondialdehyde (MDA) and Fe2+ levels, and decrease ATP and glutathione (GSH) levels, as well as Glutathione Peroxidase 4 (GPX4) and xCT expression. However, these changes induced by APAP were prevented by abietic acid, indicating abietic acid could inhibit APAP-induced Ferroptosis. Furthermore, abietic acid inhibited APAP-induced NF-κB activation and increased the expression of Nrf2 and HO-1. Additionally, the inhibitory effects of abietic acid on APAP-induced liver injury were prevented in Nrf2-/- mice. In vitro, the inhibition of abietic acid on APAP-induced inflammation and Ferroptosis were reversed when Nrf2 was knockdown. In summary, abietic acidexhibited a therapeutic effectagainst liver injury by attenuating inflammation and Ferroptosis.

Keywords

Abietic acid; Acetaminophen; Ferroptosis; Liver injury; NF-κB.

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