2. Academic Validation
  3. Lipid Prodrug Nanoassemblies via Dynamic Covalent Boronates

Lipid Prodrug Nanoassemblies via Dynamic Covalent Boronates

  • ACS Nano. 2023 Apr 11;17(7):6601-6614. doi: 10.1021/acsnano.2c12233.
Yuxun Ding 1,  Xiaowen Hu 1 2,  Yinzi Piao 1 2,  Rong Huang 3,  Lingping Xie 3,  Xiaojian Yan 3,  Hui Sun 2,  Yuanfeng Li 1,  Linqi Shi 4,  Yong Liu 1
Affiliations

Affiliations

  • 1 Translational Medicine Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China.
  • 2 College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China.
  • 3 Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
  • 4 Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
PMID: 36999933 DOI: 10.1021/acsnano.2c12233
Abstract

Prodrug nanoassemblies combine the advantages of prodrug and nanomedicines, offering great potential in targeting the lesion sites and specific on-demand drug release, maximizing the therapeutic performance while minimizing their side effects. However, there is still lacking a facile pathway to prepare the lipid prodrug nanoassemblies (LPNAs). Herein, we report the LPNAs via the dynamic covalent boronate between catechol and boronic acid. The resulting LPNAs possess properties like drug loading in a dynamic covalent manner, charge reversal in an acidic microenvironment, and specific drug release at an acidic and/or oxidative microenvironment. Our methodology enables the encapsulation and delivery of three model drugs: ciprofloxacin, bortezomib, and miconazole. Moreover, the LPNAs are often more efficient in eradicating pathogens or Cancer cells than their free counterparts, both in vitro and in vivo. Together, our LPNAs with intriguing properties may boost the development of drug delivery and facilitate their clinical applications.

Keywords

bacterial biofilms; biomedical applications; boronate; drug delivery; self-assembly.

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