2. Academic Validation
  3. Tralomethrin causes cardiovascular toxicity in zebrafish (Danio rerio) embryos

Tralomethrin causes cardiovascular toxicity in zebrafish (Danio rerio) embryos

  • Environ Toxicol. 2023 Nov;38(11):2761-2771. doi: 10.1002/tox.23911.
Shanshan Guo 1,  Yaqing Wu 2,  Wenhua Li 1,  Peng Xiao 3
Affiliations

Affiliations

  • 1 Engineering Research Center of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, School of Biomedical Sciences, Huaqiao University, Xiamen, People's Republic of China.
  • 2 Instrumental Analysis Center of Huaqiao University, Xiamen, People's Republic of China.
  • 3 National and Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution, Zhejiang Provincial Key Lab for Water Environment and Marine Biological Resources Protection, Institute for Eco-Environmental Research of Sanyang Wetland, Wenzhou University, Wenzhou, People's Republic of China.
PMID: 37471628 DOI: 10.1002/tox.23911
Abstract

Tralomethrin, a synthetic pyrethroid insecticide used to control a wide range of pests in agriculture and public health, is highly toxic to aquatic organisms. However, data regarding the toxicity and underlying mechanisms of tralomethrin in aquatic organisms are limited. Thus, this study aimed to investigate the toxicity of tralomethrin in zebrafish. Zebrafish embryos were exposed to tralomethrin at different concentrations (16.63, 33.25, and 49.88 μg/L). Results showed that tralomethrin exposure caused cardiovascular dysplasia and dysfunction, including developmental abnormalities (pericardial edema, delayed yolk absorption, and uninflated swim bladder), elevated heart rate, and erythrogenesis disorders. Moreover, the expression patterns of crucial genes responsible for cardiovascular development (alas2, gata1a, hbbe2, nkx2.5, myl7, and myh6) also exhibited dysregulation in response to tralomethrin exposure. Oxidative stress occurred in embryos after exposure to tralomethrin. Collectively, our data suggest that exposure to tralomethrin induces cardiovascular and developmental toxicity in zebrafish. These findings are instrumental for evaluations of the environmental risk of tralomethrin in aquatic ecosystems in the future.

Keywords

cardiovascular toxicity; heart failure; oxidative stress; tralomethrin; zebrafish.

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