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  3. Glymphatic Dysfunction in Migraine Mice Model

Glymphatic Dysfunction in Migraine Mice Model

  • Neuroscience. 2023 Jul 28;S0306-4522(23)00336-6. doi: 10.1016/j.neuroscience.2023.07.027.
Wanbin Huang 1,  Yu Zhang 1,  Yanjie Zhou 1,  Jiabin Zong 2,  Tao Qiu 1,  Luyu Hu 1,  Songqing Pan 1,  Zheman Xiao 3
Affiliations

Affiliations

  • 1 Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • 2 Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  • 3 Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address: zmxiao@whu.edu.cn.
PMID: 37516436 DOI: 10.1016/j.neuroscience.2023.07.027
Abstract

The glymphatic system is important for waste removal in the central nervous system. It removes soluble proteins and metabolic waste under the action of aquaporin-4 (AQP4) at the end of astrocytes. The glymphatic system plays a role in numerous neurological diseases; however, the relationship between migraine and the glymphatic system remains unclear. In this study, we explored the relationship between the glymphatic system and migraine using the nitroglycerin migraine model in C57/BL6mice. The glymphatic influx of cerebrospinal fluid tracer was reduced in mice in the migraine model, accompanied by decreased expression and impaired polarization of AQP4, thereby suggesting glymphatic dysfunction in migraine mice model. Then, further suppression of glymphatic function by TGN-020 (an AQP4 blocker) aggravated the migraine pathological changes in mice. The results indicated that glymphatic dysfunction may aggravate migraine pathology. Therefore, our findings revealed the potential role of the glymphatic system in migraine, providing possible targets for migraine prevention and treatment.

Keywords

AQP4; CGRP; glymphatic system; migraine; neuroinflammation.

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