2. Academic Validation
  3. Activity of the new OSBP inhibitor Y18501 against Pseudoperonospora cubensis and its application for the control of cucumber downy mildew

Activity of the new OSBP inhibitor Y18501 against Pseudoperonospora cubensis and its application for the control of cucumber downy mildew

  • Pestic Biochem Physiol. 2023 Aug;194:105415. doi: 10.1016/j.pestbp.2023.105415.
Bin Wang 1,  Zhaolin Xue 2,  Jie Lan 3,  Mingyou Sun 3,  Qin Sun 3,  Zhongqiao Huang 2,  Can Zhang 4,  Xili Liu 5
Affiliations

Affiliations

  • 1 Department of Plant Pathology, College of Plant Protection, China Agricultural University, 2 Yuanmingyuan Road, Beijing 100193, China; State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Sinochem Agrochemicals R&D Co. Ltd, 8 Shenliao East Road, Shenyang 110021, Liaoning, China.
  • 2 Department of Plant Pathology, College of Plant Protection, China Agricultural University, 2 Yuanmingyuan Road, Beijing 100193, China.
  • 3 State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Sinochem Agrochemicals R&D Co. Ltd, 8 Shenliao East Road, Shenyang 110021, Liaoning, China.
  • 4 Department of Plant Pathology, College of Plant Protection, China Agricultural University, 2 Yuanmingyuan Road, Beijing 100193, China. Electronic address: czhang@cau.edu.cn.
  • 5 Department of Plant Pathology, College of Plant Protection, China Agricultural University, 2 Yuanmingyuan Road, Beijing 100193, China; State Key Laboratory of Crop Stress Biology for Arid Arears, College of Plant Protection, Northwest A&F University, 3 Taicheng Road, Yangling 712100, Shaanxi, China. Electronic address: seedling@cau.edu.cn.
PMID: 37532305 DOI: 10.1016/j.pestbp.2023.105415
Abstract

Y18501 is a new oxysterol-binding protein inhibitor (OSBPI) with a similar structure to oxathiapiprolin. Y18501 showed strong inhibitory activities against Phytophthora spp. and Pseudoperonospora cubensis, with EC50 ranging from 0.0005 to 0.0046 μg/mL. It also had good control efficacy on cucumber downy mildew (CDM) in the green house and in the field, and could effectively inhibit different development stages of P. cubensis, especially for sporangiophore production, sporangial production, mycelium extension, and elongation of germ tube. In addition, Y18501 showed excellent protective and curative activities against P. cubensis. It also had acropetal systemic mobility in the cucumber leaves, and could be taken up and translocated to the upper leaves more effectively from the lower leaves than from the roots. Y18501 had poorer permeability in cucumber leaves compared to oxathiapiprolin. The simultaneous application of Y18501 and chlorothalonil could significantly promote the inhibition of P. cubensis.

Keywords

Control efficacy; Inhibitory activity; OSBPIs; Permeability; Pseudoperonospora cubensis; Systemic mobility.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-155131
    OSBP Inhibitor