Y18501 

Y18501 is a oxysterol-binding protein (OSBPI) inhibitor with a similar structure to Oxathiapiprolin. Y18501 shows strong inhibitory activities against Phytophthora spp. and Pseudoperonospora cubensis, with EC₅₀ ranging from 0.0005 to 0.0046 μg/mL. Y18501 shows excellent protective and curative activities against P. cubensis. Y18501 in combination with Chlorothalonil (HY-N6625) can significantly promote the inhibition of P. cubensis^[1].

Y18501 (at application rates of 25 g a.i./ha or 50 g a.i./ha) has over 60% control efficacy on cucumber downy mildew under the green house conditions^[1].
Y18501 shows control efficacy against CDM in P. cubensis both in the green house and in the field, showing 72.3% and 78.9% control efficacy at an application rate of 25 g a.i./ha, as well as 80.8% and 82.2% control efficacy at an application rate of 50 g a.i./ha, respectively^[1].
Y1850 (10.012-0.333 μg/mL) is greater than the curative activity, resulting in a control efficacy of 70.11–99.43% against CDM in P. cubensis when it is applied 24 h pre-inoculation, which is significantly higher than when applied 24 h post-inoculation^[1].
Y18501 and Chlorothalonil (HY-N6625) (at the ratios of 1:100, 1:70, and 1:50) has a higher synergistic action against P. cubensis, with synergistic ratios of 2.00, 1.83, and 2.64, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

536.60

C₂₇H₂₆F₂N₆O₂S

2410627-32-4

CCC1=NN(CC(N2CCC(C3=NC(C4=NOC(C5=C(F)C=CC=C5F)C4)=CS3)CC2)=O)C6=C1C=CC=N6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang B, et al. Activity of the new OSBP inhibitor Y18501 against Pseudoperonospora cubensis and its application for the control of cucumber downy mildew. Pestic Biochem Physiol. 2023;194:105415.  [Content Brief]