2. Academic Validation
  3. Kangfuxin liquid reduces the ultraviolet B-induced photodamage of HaCaT cells by regulating autophagy

Kangfuxin liquid reduces the ultraviolet B-induced photodamage of HaCaT cells by regulating autophagy

  • Biosci Biotechnol Biochem. 2023 Sep 8;zbad130. doi: 10.1093/bbb/zbad130.
Xianghong Lin 1,  Jimin Chu 2,  Yang Xiang 3,  Miao He 4,  Qiong Ma 5,  Jingxian Duan 5,  Yan Wang 5,  Sujiao Sun 5
Affiliations

Affiliations

  • 1 College of Clinical Medicine, Dali University, Dali, Yunnan, China.
  • 2 Department of Skin Medical Beauty, People's Hospital of Pengshui County, Pengshui, Chongqing, China.
  • 3 Key Laboratory of Human Aging in Jiangxi Province, Nanchang University, Nanchang, Jiangxi, China.
  • 4 College of Pharmacy and Chemistry, Dali University, Dali, Yunnan, China.
  • 5 Department of Medical Cosmetology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China.
PMID: 37682519 DOI: 10.1093/bbb/zbad130
Abstract

Kangfuxin liquid (KFX), an extract of the American cockroach, has been clinically proven to be effective in various skin damage disorders, but there are no reports on its use in photodamage. We explored the effect of KFX on ultraviolet B (UVB) induced photodamage and whether its mechanism was related to Autophagy. We found that KFX treatment reduced UVB induced Reactive Oxygen Species (ROS) production and improved the vitality of cells inhibited by UVB irradiation. The expression of LC3 (A/B), which was inhibited after UVB irradiation, could be rescued by KFX treatment. Furthermore, KFX may upregulate the level of cellular Autophagy by regulating the AMPK-mTOR signaling pathway. When the Autophagy Inhibitor wortmannin was used to inhibit Autophagy, the protective effect of KFX on cells was diminished or even disappeared. Our study suggests that KFX may resist UVB-mediated oxidative stress damage of HaCaT through the induction of Autophagy.

Keywords

HaCaT; autophagy; kangfuxin liquid; photodamage; ultraviolet B.

Figures
Products
Inhibitors & Agonists
Other Products