2. Academic Validation
  3. Structural characteristics and structure-activity relationship of four polysaccharides from Lycii fructus

Structural characteristics and structure-activity relationship of four polysaccharides from Lycii fructus

  • Int J Biol Macromol. 2023 Oct 5;253(Pt 5):127256. doi: 10.1016/j.ijbiomac.2023.127256.
Xiaofei Liang 1,  Mengqiu Liu 1,  Yan Wei 1,  Limei Tong 1,  Sheng Guo 1,  Hongjie Kang 2,  Wenhua Zhang 3,  Zhexiong Yu 4,  Fang Zhang 5,  Jin-Ao Duan 6
Affiliations

Affiliations

  • 1 Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, PR China.
  • 2 Ningxia Innovation Center of Goji R & D, Yinchuan 750002, PR China.
  • 3 Bairuiyuan Gouqi Co., Ltd., Yinchuan 750200, PR China.
  • 4 Tianren Ningxia Wolfberry Biotechnology Co., Ltd., Zhongning 755100, PR China.
  • 5 Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, PR China. Electronic address: fangzhang@njucm.edu.cn.
  • 6 Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, PR China. Electronic address: dja@njucm.edu.cn.
PMID: 37802446 DOI: 10.1016/j.ijbiomac.2023.127256
Abstract

At present, the structure-activity relationship of Polysaccharides is a common and important focus in the fields of glycobiology and carbohydrate chemistry. To better understand the effect of specific polysaccharide structures on bioactive orientation, four homogeneous Polysaccharides from Lycii fructus, one neutral along with three acidic Polysaccharides, were purified, structurally characterized and comparatively evaluated on the antioxidative and Anti-aging activities. The GC-MS-based monosaccharide composition analysis and methylation results showed that the LFPs had similar glycosyl types but varied proportions. Nuclear magnetic resonance (NMR) spectroscopy showed that LFPs consisted of arabinogalactan, rhamnogalacturonan and homogalacturonan structural domains. The results of the structure-activity relationship indicated that the antioxidative activity was positively correlated with the galacturonic acid (GalA) content, while the neutral multi-branched chains might be responsible for the Anti-aging activity. This study is the first time to compare the principal structures and multiple biological activities of LFPs, which provided a reference for the industrial development and deep excavation of the health value of LFPs.

Keywords

Lycii fructus; Polysaccharides; Structural characteristics; Structure-activity relationship.

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