2. Academic Validation
  3. Inhibition of excessive autophagy alleviates renal injury and inflammation in a rat model of immunoglobulin A nephropathy

Inhibition of excessive autophagy alleviates renal injury and inflammation in a rat model of immunoglobulin A nephropathy

  • Eur J Pharmacol. 2023 Nov 14:176198. doi: 10.1016/j.ejphar.2023.176198.
Meiying Chang 1,  Xiujie Shi 2,  Sijia Ma 2,  Mingming Zhao 2,  Jiao Fan 2,  Zhiyu Pan 2,  Shunxuan Xue 2,  Ziyan Zhang 2,  Zhenwei Shi 3,  Bin Yang 4,  Yu Zhang 5
Affiliations

Affiliations

  • 1 Department of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China; Department of Nephrology, The First Hospital of Tsinghua University, Beijing, 100016, China.
  • 2 Department of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
  • 3 Department of Nephrology, The First Hospital of Tsinghua University, Beijing, 100016, China. Electronic address: shizhenwei2075@mail.tsinghua.edu.cn.
  • 4 Department of Pathology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. Electronic address: yangbin555@126.com.
  • 5 Department of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. Electronic address: zhangyu8225@126.com.
PMID: 37972847 DOI: 10.1016/j.ejphar.2023.176198
Abstract

The pathogenesis of immunoglobulin A nephropathy (IgAN) is closely related to immunity and inflammation. The clinical process of IgAN varies greatly, making the assessment of prognosis challenging and limiting progress on effective treatment measures. Autophagy is an important pathway for the development of IgAN. However, the role of Autophagy in IgAN is complex, and the consequences of Autophagy may change during disease progression. In the present study, we evaluated the dynamic changes in Autophagy during IgAN. Specifically, we examined Autophagy in the kidney of a rat model of IgAN at different time points. We found that Autophagy was markedly and persistently induced in IgAN rats, and the expression level of inflammation was also persistently elevated. The Autophagy enhancer rapamycin and Autophagy Inhibitor 3-methyladenine were used in this study, and the results showed that 3-methyladenine can alleviate renal injury and inflammation in IgAN rats. Our study provides further evidence for Autophagy as a therapeutic target for IgAN.

Keywords

3-Methyladenine; Autophagy; Immunoglobulin A nephropathy; Inflammation; Renal injury.

Figures
Products