2. Academic Validation
  3. Controllably Self-Assembled Antibacterial Nanofibrils Based on Insect Cuticle Protein for Infectious Wound Healing

Controllably Self-Assembled Antibacterial Nanofibrils Based on Insect Cuticle Protein for Infectious Wound Healing

  • ACS Nano. 2023 Nov 20. doi: 10.1021/acsnano.3c07131.
Qiuyu Gong 1 2 3,  Bohao Liu 1 2,  Fenghou Yuan 4,  Runyi Tao 1 2,  Yinjuan Huang 5,  Xiaoyan Zeng 6,  Xingzhuo Zhu 1 2,  Yilong Zhao 1 2,  Yanpeng Zhang 1 2,  Mei Yang 1 2,  Jizhao Wang 1 2,  Tian Liu 4,  Guangjian Zhang 1 2
Affiliations

Affiliations

  • 1 Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P. R. China.
  • 2 Key Laboratory of Enhanced Recovery After Surgery of Integrated Chinese and Western Medicine, Administration of Traditional Chinese Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P. R. China.
  • 3 Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, Ministry of Education, Qingdao University of Science and Technology, Qingdao 266042, P. R. China.
  • 4 School of Bioengineering, Dalian University of Technology, Dalian 116024, P. R. China.
  • 5 State Key Laboratory for Mechanical Behavior of Materials, Shaanxi International Research Center for Soft Matter, School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
  • 6 Department of Laboratory Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P. R. China.
PMID: 37983051 DOI: 10.1021/acsnano.3c07131
Abstract

Developing self-assembled biomedical Materials based on insect proteins is highly desirable due to their advantages of green, rich, and sustainable characters as well as excellent biocompatibility, which has been rarely explored. Herein, salt-induced controllable self-assembly, Antibacterial performance, and infectious wound healing performance of an insect cuticle protein (OfCPH-2) originating from the Ostrinia furnacalis larva head capsule are investigated. Interestingly, the addition of salts could trigger the formation of beaded nanofibrils with uniform diameter, whose length highly depends on the salt concentration. Surprisingly, the OfCPH-2 nanofibrils not only could form functional films with broad-spectrum Antibacterial abilities but also could promote infectious wound healing. More importantly, a possible wound healing mechanism was proposed, and it is the strong abilities of OfCPH-2 nanofibrils in promoting vascular formation and Antibacterial activity that facilitate the process of infectious wound healing. Our exciting findings put forward instructive thoughts for developing innovative bioinspired Materials based on insect proteins for wound healing and related biomedical fields.

Keywords

Ostrinia furnacalis; bioinspired materials; cuticle protein; vascular formation; wound healing.

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