2. Academic Validation
  3. BiTiS3 bio-transducer with explosive on-demand generation of NO gas for synergetic cancer therapy

BiTiS3 bio-transducer with explosive on-demand generation of NO gas for synergetic cancer therapy

  • Biosens Bioelectron. 2024 Feb 15:246:115895. doi: 10.1016/j.bios.2023.115895.
Mingyang Jiang 1,  Ziqiang Cheng 2,  Tingting Luo 1,  Chenchen Chu 1,  Zhenyu Zhang 1,  Yun Hui 1,  Paul K Chu 3,  Xue-Feng Yu 1,  Jiahong Wang 4,  Wenhua Zhou 5,  Shengyong Geng 6
Affiliations

Affiliations

  • 1 Shenzhen Key Laboratory of Micro/Nano Biosensing, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
  • 2 Department of Applied Physics, School of Science, East China Jiaotong University, Nanchang, 330013, China.
  • 3 Department of Physics, Department of Materials Science and Engineering, and Department of Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong.
  • 4 Shenzhen Key Laboratory of Micro/Nano Biosensing, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. Electronic address: jh.wang1@siat.ac.cn.
  • 5 Shenzhen Key Laboratory of Micro/Nano Biosensing, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. Electronic address: wh.zhou@siat.ac.cn.
  • 6 Shenzhen Key Laboratory of Micro/Nano Biosensing, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. Electronic address: sy.geng@siat.ac.cn.
PMID: 38048720 DOI: 10.1016/j.bios.2023.115895
Abstract

Combined photothermal therapy and nitric oxide (NO)-mediated gas therapy has shown great potential as a Cancer treatment. However, the on-demand release of NO at a high concentration presents a challenge owing to the lack of an ideal bio-transducer with a high loading capacity of NO donors and sufficient energy to induce NO release. Here, we present a new 2D BiTiS3 nanosheet that is synthesized, loaded with the NO donor (BNN6), and conjugated with PEG-iRGD to produce a multifunctional bio-transducer (BNN6-BiTiS3-iRGD) for the on-demand production of NO. The BiTiS3 nanosheets not only have a high loading capacity of NO donors (750%), but also exhibit a high photothermal conversion efficiency (59.5%) after irradiation by a 1064-nm laser at 0.5 W/cm2. As a result of the above advantages, the temporal-controllable generation of NO within a large dynamic range (from 0 to 344 μM) is achieved by adjusting power densities, which is among the highest efficiency values reported for NO generators so far. Moreover, the targeted accumulation of BNN6-BiTiS3-iRGD at tumor sites leads to spatial-controllable NO release. In vitro and in vivo assessments demonstrate synergistic NO gas therapy with mild photothermal therapy based on BNN6-BiTiS3-iRGD. Our work provides insights into the design and application of other 2D nanomaterial-based therapeutic platforms.

Keywords

BiTiS(3) nanosheets; High dosage; NO gas; Spatiotemporal controllability; Synergetic cancer therapy.

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