2. Academic Validation
  3. Exploring BODIPY derivatives as sonosensitizers for anticancer sonodynamic therapy

Exploring BODIPY derivatives as sonosensitizers for anticancer sonodynamic therapy

  • Eur J Med Chem. 2023 Dec 9:264:116035. doi: 10.1016/j.ejmech.2023.116035.
Xudong Li 1,  Xianbin Sun 1,  Hui Chen 2,  Xinyu Chen 1,  Yuanming Li 1,  Dongmiao Li 3,  Zizhong Zhang 3,  Haijun Chen 4,  Yu Gao 5
Affiliations

Affiliations

  • 1 Cancer Metastasis Alert and Prevention Center, College of Chemistry, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China.
  • 2 Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China.
  • 3 State Key Lab of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China.
  • 4 Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China. Electronic address: chenhaij@gmail.com.
  • 5 Cancer Metastasis Alert and Prevention Center, College of Chemistry, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350108, China. Electronic address: hellogaoyu@126.com.
PMID: 38101040 DOI: 10.1016/j.ejmech.2023.116035
Abstract

Sonodynamic therapy (SDT) is an emerging non-invasive and effective therapeutic modality for Cancer treatment bearing benefit of deep tissue-penetration in comparison to photo-inspired therapy. However, exploring novel sonosensitizers with high sonosensitivity and desirable biosafety remains a significant challenge. Although boron dipyrromethene (BODIPY) dyes have been widely used in biomedical filed, no BODIPY-based sonosensitizers have been reported yet. Herein, we synthesized four BODIPY dyes (BDP1-BDP4) and investigated their potential applications in SDT. BDP4 exhibited superb sonosensitivity and high SDT efficiency against Cancer cells and tumors in tumor-bearing mice. The types of the generated Reactive Oxygen Species, cavitation effect, and cell Apoptosis were investigated to figure out the sonodynamic therapeutic mechanisms of BDP4. This work for the first time demonstrates the potential of BODIPY dyes as novel sonosensitizers for SDT, which may pave an avenue for developing more efficient and safer sonosensitizers in future.

Keywords

BODIPY; Cancer treatment; Sonodynamic therapy.

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