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  3. Photothermal therapy of tuberculosis using targeting pre-activated macrophage membrane-coated nanoparticles

Photothermal therapy of tuberculosis using targeting pre-activated macrophage membrane-coated nanoparticles

  • Nat Nanotechnol. 2024 Feb 21. doi: 10.1038/s41565-024-01618-0.
Bin Li # 1 2 3,  Wei Wang # 1,  Lu Zhao # 3,  Yunxia Wu # 3,  Xiaoxue Li 1,  Dingyuan Yan 4,  Qiuxia Gao 3,  Yan Yan 5,  Jie Zhang 6,  Yi Feng 1,  Judun Zheng 1,  Bowen Shu 1,  Jiamei Wang 1,  Huanhuan Wang 1,  Lingjie He 1,  Yunlong Zhang 5,  Mingliang Pan 5,  Dong Wang 7,  Ben Zhong Tang 8 9,  Yuhui Liao 10 11
Affiliations

Affiliations

  • 1 Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital of Southern Medical University, Guangzhou, China.
  • 2 School of Inspection, Ningxia Medical University, Yinchuan, China.
  • 3 Institute of Translational Medicine, Department of Clinical Laboratory & Department of Burn Surgery, The First People's Hospital of Foshan, Foshan, China.
  • 4 Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, China.
  • 5 Department of Critical Care Medicine, Department of Emergency, Renmin Hospital of Wuhan University, Wuhan, China.
  • 6 Engineering Research Center of Tibetan Medicine Detection Technology, Ministry of Education, Xizang Minzu University, Xianyang, China.
  • 7 Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, China. wangd@szu.edu.cn.
  • 8 Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, China. tangbenz@cuhk.edu.cn.
  • 9 School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen, China. tangbenz@cuhk.edu.cn.
  • 10 Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital of Southern Medical University, Guangzhou, China. liaoyh8@mail.sysu.edu.cn.
  • 11 School of Inspection, Ningxia Medical University, Yinchuan, China. liaoyh8@mail.sysu.edu.cn.
  • # Contributed equally.
PMID: 38383890 DOI: 10.1038/s41565-024-01618-0
Abstract

Conventional Antibiotics used for treating tuberculosis (TB) suffer from drug resistance and multiple complications. Here we propose a lesion-pathogen dual-targeting strategy for the management of TB by coating Mycobacterium-stimulated macrophage membranes onto polymeric cores encapsulated with an aggregation-induced emission photothermal agent that is excitable with a 1,064 nm laser. The coated nanoparticles carry specific receptors for Mycobacterium tuberculosis, which enables them to target tuberculous granulomas and internal M. tuberculosis simultaneously. In a mouse model of TB, intravenously injected nanoparticles image individual granulomas in situ in the lungs via signal emission in the near-infrared region IIb, with an imaging resolution much higher than that of clinical computed tomography. With 1,064 nm laser irradiation from outside the thoracic cavity, the photothermal effect generated by these nanoparticles eradicates the targeted M. tuberculosis and alleviates pathological damage and excessive inflammation in the lungs, resulting in a better therapeutic efficacy compared with a combination of first-line Antibiotics. This precise photothermal modality that uses dual-targeted imaging in the near-infrared region IIb demonstrates a theranostic strategy for TB management.

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