2. Academic Validation
  3. Anti-Inflammatory Salicin Derivatives from the Barks of Salix tetrasperma

Anti-Inflammatory Salicin Derivatives from the Barks of Salix tetrasperma

  • J Agric Food Chem. 2024 Apr 11. doi: 10.1021/acs.jafc.4c01061.
Pei-Qian Wu 1,  Ying Li 2,  Yu-Hao Ren 1,  Jun-Su Zhou 1,  Qun-Fang Liu 1,  Yan Wu 1,  Jin-Hai Yu 2,  Bin Zhou 1 2,  Jian-Min Yue 1 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
  • 2 Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, Shandong, People's Republic of China.
PMID: 38602386 DOI: 10.1021/acs.jafc.4c01061
Abstract

The genus Salix L. is traditionally used in folk medicine to alleviate pain caused by various kinds of inflammation. In the present study, 10 undescribed salicin derivatives along with 5 known congeners were isolated from the barks of Salix tetrasperma, and their structures were elucidated by spectroscopic analyses, single-crystal X-ray diffraction, electronic circular dichroism (ECD) calculations, and chemical conversions. Compounds 4-6 significantly inhibited NO production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages, and the most active 4 obviously suppressed the production of IL-1β and IL-6 and decreased iNOS and COX-2 expression in a dose-dependent manner. Further Western blotting analysis revealed that the anti-inflammatory mechanism of 4 is possibly mediated through the MAPK and NF-κB signaling pathways.

Keywords

Salix tetrasperma; anti-inflammatory activity; salicin derivatives; structural elucidation.

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