Salixteroside D

Cat. No.: HY-N12767: FAQs
Data Sheet Handling Instructions

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Salixteroside D is a salicin derivative, that exhibits anti-inflammatory activity through inhibition of MAPK and NF-κB signaling pathways.

For research use only. We do not sell to patients.

Salixteroside D Chemical Structure

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

Biological Activity
Purity & Documentation
References
Customer Review

Description

Salixteroside D is a salicin derivative, that exhibits anti-inflammatory activity through inhibition of MAPK and NF-κB signaling pathways^[1].

In Vitro

Salixteroside D (20 μM, 24 h) inhibits NO production in RAW 264.7 with an IC₅₀ of 6.75 μM, without cytotoxicity in cell RAW 264.7^[1].
Salixteroside D (5-20 μM, 12 h) inhibits the expressions of inflammatory mediators IL-1β, IL-6, iNOS and COX-2 in Lipopolysaccharides (HY-D1056)-induced RAW 264.7 macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	RAW 264.7
Concentration:	5-20 μM
Incubation Time:	12 h
Result:	Decreased mRNA levels of iNOS and COX-2.

Molecular Weight

466.44

Formula

C₂₂H₂₆O₁₁

SMILES

CC(OC1[C@H]([C@@H](O[C@@H]([C@H]1O)CO)OC2=CC=CC=C2COC([C@@]3(C=CCCC3=O)O)=O)O)=O

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu PQ, et al., Anti-Inflammatory Salicin Derivatives from the Barks of Salix tetrasperma. J Agric Food Chem. 2024 Apr 11. [Content Brief]

Salixteroside D Related Classifications

Inflammation/Immunology

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Salixteroside Dp38 MAPKNF-κBNuclear factor-κBNuclear factor-kappaBRAW 264.7macrophagesalicinInhibitorinhibitorinhibit

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