1. Academic Validation
  2. Mineral crude drug mirabilite (Mangxiao) inhibits the occurrence of colorectal cancer by regulating the Lactobacillus-bile acid-intestinal farnesoid X receptor axis based on multiomics integration analysis

Mineral crude drug mirabilite (Mangxiao) inhibits the occurrence of colorectal cancer by regulating the Lactobacillus-bile acid-intestinal farnesoid X receptor axis based on multiomics integration analysis

  • MedComm (2020). 2024 Apr 25;5(5):e556. doi: 10.1002/mco2.556.
Xiaohang Zhou 1 Hui Sun 1 Junling Ren 1 Guangli Yan 1 Le Yang 2 Honglian Zhang 3 Haitao Lu 4 5 Xinghua Li 1 Toshiaki Makino 6 Fengting Yin 1 Jing Li 1 Xijun Wang 1 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Integration and Innovation of Classical Formula and Modern Chinese Medicine National Chinmedomics Research Center National TCM Key Laboratory of Serum Pharmacochemistry Metabolomics Laboratory Department of Pharmaceutical Analysis Heilongjiang University of Chinese Medicine Harbin China.
  • 2 State Key Laboratory of Dampness Syndrome The Second Affiliated Hospital Guangzhou University of Chinese Medicine Guangzhou China.
  • 3 Department of Traditional Chinese Medicine, Pharmacy College Qiqihar Medical University Qiqihar China.
  • 4 Hong Kong Traditional Chinese Medicine Phenome Research Centre, School of Chinese Medicine Hong Kong Baptist University Hong Kong China.
  • 5 State Key Laboratory of Environmental and Biological Analysis Hong Kong Baptist University Hong Kong China.
  • 6 Department of Pharmacognosy Graduate School of Pharmaceutical Sciences Nagoya City University Nagoya Japan.
Abstract

Mineral crude drug has revolutionized the treatment landscape in precision oncology niche that leads to the improvement in therapeutic efficiency on various tumor subtypes. Mangxiao (MX), a mineral crude drug in traditional Chinese medicine, has been used for treating gastrointestinal diseases for thousands of years. However, the action mechanisms are still ambiguous. Here, we attempt to explore inhibitory roles and associated pharmacological mechanisms of MX upon colorectal Cancer (CRC) in APCMin/+ male mice by integrating metabolomics, 16S rDNA Sequencing analyses, and metagenomic-based microbiota analysis. We found that MX can significantly inhibit the occurrence of CRC through the regulation of the dysregulated gut microbe metabolism. Furthermore, the correlation analysis of metabolomes and 16S rDNA revealed that MX could restore the disorders of gut microbes by specifically enriching the abundance of Lactobacilli to improve bile acid metabolism, which further activated the farnesoid X receptor (FXR) in CRC mice, then the improvement of gut dysbiosis could inhibit the development of CRC. Collectively, our effort confirmed MX has the capacity to intervene the development of CRC and further discovered that it targets Lactobacillus-bile acid-intestinal FXR axis, which can be regarded as a candidate medicine for future drug discovery and development against CRC.

Keywords

Mangxiao; colorectal cancer; multiomics; traditional Chinese medicine.

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