1. Academic Validation
  2. Tumour-derived exosome SNHG17 induced by oestrogen contributes to ovarian cancer progression via the CCL13-CCR2-M2 macrophage axis

Tumour-derived exosome SNHG17 induced by oestrogen contributes to ovarian cancer progression via the CCL13-CCR2-M2 macrophage axis

  • J Cell Mol Med. 2024 May;28(9):e18315. doi: 10.1111/jcmm.18315.
Haiyan Liang 1 Shuo Geng 1 Yadong Wang 2 Qing Fang 3 Yongfeng Xin 4 Yanqing Li 5
Affiliations

Affiliations

  • 1 Department of Obstetrics and Gynecology, China-Japan Friendship Hospital, Beijing, China.
  • 2 Scientific Research Department, GeneX Health Co., Ltd, Beijing, China.
  • 3 Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, China.
  • 4 Department of Gynecology, The People's Hospital of DaLaTe, Ordos, Inner Mongolia, China.
  • 5 Department of Gynecology, Hebei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hebei, China.
Abstract

Oestrogen is known to be strongly associated with ovarian Cancer. There was much work to show the importance of lncRNA SNHG17 in ovarian Cancer. However, no study has revealed the molecular regulatory mechanism and functional effects between oestrogen and SNHG17 in the development and metastasis of ovarian Cancer. In this study, we found that SNHG17 expression was significantly increased in ovarian Cancer and positively correlated with oestrogen treatment. Oestrogen could promote M2 macrophage polarization as well as ovarian Cancer cells SKOV3 and ES2 cell exosomal SNHG17 expression. When exposure to oestrogen, exosomal SNHG17 promoted ovarian Cancer cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) in vitro, and tumour growth and lung metastasis in vivo by accelerating M2-like phenotype of macrophages. Mechanically, exosomal SNHG17 could facilitate the release of CCL13 from M2 macrophage via the PI3K-Akt signalling pathway. Moreover, CCL13-CCR2 axis was identified to be involved in ovarian Cancer tumour behaviours driven by oestrogen. There results demonstrate a novel mechanism that exosomal SNHG17 exerts an oncogenic effect on ovarian Cancer via the CCL13-CCR2-M2 macrophage axis upon oestrogen treatment, of which SNHG17 may be a potential biomarker and therapeutic target for ovarian Cancer responded to oestrogen.

Keywords

M2 macrophage; exosomal SNHG17; oestrogen; ovarian cancer.

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