2. Academic Validation
  3. Polyacrylic Acid-Coated Selenium-Doped Carbon Dots Inhibit Ferroptosis to Alleviate Chemotherapy-Associated Acute Kidney Injury

Polyacrylic Acid-Coated Selenium-Doped Carbon Dots Inhibit Ferroptosis to Alleviate Chemotherapy-Associated Acute Kidney Injury

  • Adv Sci (Weinh). 2024 Apr 30:e2400527. doi: 10.1002/advs.202400527.
Jiahuan Li 1 2,  Chengcheng Fu 2 3 4 5,  Baoli Feng 1 2,  Qingquan Liu 6,  Jiangjiang Gu 7,  Mohammad Nauman Khan 8,  Lvhui Sun 1 2,  Honghong Wu 2 3 4 5,  Hao Wu 1 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Agricultural Microbiology, College of Animal Science & Technology and College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.
  • 2 Hubei Hongshan Laboratory, Wuhan, 430070, China.
  • 3 MOA Key Laboratory of Crop Ecophysiology and Farming System in the Middle Reaches of the Yangtze River, College of Plant Science & Technology, Huazhong Agricultural University, Wuhan, 430070, China.
  • 4 Shenzhen Institute of Nutrition and Health, Huazhong Agricultural University, Wuhan, 430070, China.
  • 5 Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518120, China.
  • 6 Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • 7 College of Chemistry, Huazhong Agricultural University, Wuhan, 430070, China.
  • 8 School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University, Sanya, 572000, China.
PMID: 38689508 DOI: 10.1002/advs.202400527
Abstract

Cisplatin-associated acute kidney injury (AKI) is a severe clinical syndrome that significantly restricts the chemotherapeutic application of cisplatin in Cancer patients. Ferroptosis, a newly characterized programmed cell death driven by the lethal accumulation of lipid peroxidation, is widely reported to be involved in the pathogenesis of cisplatin-associated AKI. Targeted inhibition of Ferroptosis holds great promise for developing novel therapeutics to alleviate AKI. Unfortunately, current Ferroptosis inhibitors possess low bioavailability or perform non-specific accumulation in the body, making them inefficient in alleviating cisplatin-associated AKI or inadvertently reducing the anti-tumor efficacy of cisplatin, thus not suitable for clinical application. In this study, a novel selenium nanomaterial, polyacrylic acid-coated selenium-doped carbon dots (SeCD), is rationally developed. SeCD exhibits high biocompatibility and specifically accumulates in the kidney. Administration of SeCD effectively scavenges broad-spectrum Reactive Oxygen Species and significantly facilitates GPX4 expression by releasing selenium, resulting in strong mitigation of Ferroptosis in renal tubular epithelial cells and substantial alleviation of cisplatin-associated AKI, without compromising the chemotherapeutic efficacy of cisplatin. This study highlights a novel and promising therapeutic approach for the clinical prevention of AKI in Cancer patients undergoing cisplatin chemotherapy.

Keywords

acute kidney injury; carbon dots; cisplatin; ferroptosis; selenium.

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