2. Academic Validation
  3. Porphyrins with combinations of 4-carboxyphenyl and 4-hydroxyphenyl substituents in meso-positions as anti-HIV-1 agents

Porphyrins with combinations of 4-carboxyphenyl and 4-hydroxyphenyl substituents in meso-positions as anti-HIV-1 agents

  • Sci Rep. 2024 May 1;14(1):10006. doi: 10.1038/s41598-024-60728-w.
Debdulal Sharma # 1,  Aradhana Singh # 2,  Sanaullah Safi 2,  Ritu Gaur 3,  Devashish Sengupta 4
Affiliations

Affiliations

  • 1 Department of Chemistry, Assam University, Silchar, Assam, 788011, India.
  • 2 Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi, 110068, India.
  • 3 Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi, 110068, India. rgaur@sau.ac.in.
  • 4 Department of Chemistry, Assam University, Silchar, Assam, 788011, India. devashish.sengupta@uni.sydney.edu.au.
  • # Contributed equally.
PMID: 38693160 DOI: 10.1038/s41598-024-60728-w
Abstract

A series of 4-carboxyphenyl/4-hydroxyphenyl meso-substituted porphyrins were synthesized, purified, and characterized. The compounds exhibited anti-HIV-1 activities, in vitro, under both non-photodynamic (non-PDT) and photodynamic (PDT) conditions. Specifically, the porphyrins inhibited HIV-1 virus entry, with c-PB2(OH)2 and PB(OH)3 showing significant anti-HIV-1 activity. All of the porphyrins inhibited HIV-1 subtype B and C virus entry under PDT conditions. Our study demonstrated that the compounds bearing combinations of 4-carboxyphenyl/4-hydroxyphenyl moieties were not toxic even at higher concentrations, as compared to the reference porphyrins 5,10,15,20-tetra-(4-carboxyphenyl)porphyrin (TCPP) and 5,10,15,20-tetra-(4-hydroxyphenyl)porphyrin (THPP), under PDT conditions. This study underscores the promising potential of these compounds as HIV entry inhibitors in both non-PDT and PDT scenarios.

Keywords

Photodynamic therapy; Photoinactivation of viruses; Photosensitizers; Porphyrins.

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