2. Academic Validation
  3. PPP1r18 promotes tumor progression in esophageal squamous cell carcinoma by regulating the calcineurin-mediated ERK pathway

PPP1r18 promotes tumor progression in esophageal squamous cell carcinoma by regulating the calcineurin-mediated ERK pathway

  • Carcinogenesis. 2024 May 8:bgae028. doi: 10.1093/carcin/bgae028.
Changhao Ren 1 2,  Linfeng Wu 3 4,  Shaoyuan Zhang 1 2,  Kangwei Qi 5,  Yifei Zhang 3 4,  Jiacheng Xu 3 4,  Yuanyuan Ruan 5,  Mingxiang Feng 1 2
Affiliations

Affiliations

  • 1 Department of Thoracic Surgery, Zhongshan Hospital Fudan University, Shanghai 200032, China.
  • 2 Cancer Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
  • 3 Department of Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
  • 4 Department of Endoscopy, Shanghai Collaborative Innovation Center, Shanghai, China.
  • 5 Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
PMID: 38715543 DOI: 10.1093/carcin/bgae028
Abstract

Esophageal Cancer is one of the most common malignant tumors, and the 5-year overall survival rate is only 20%. Esophageal squamous cell carcinoma (ESCC) is the primary histological type of esophageal carcinoma in China. Protein Phosphatase 1 regulatory subunit 18 (PPP1r18) is one of the actin-regulatory proteins and is able to bind to protein Phosphatase 1 catalytic subunit alpha (PPP1CA). Yet, little is known about the role of PPP1r18 in esophageal squamous cell carcinoma (ESCC). This study aimed to elucidate the biological functions of PPP1r18 in the ESCC progression. Clinical samples first confirmed that PPP1r18 expression was upregulated in ESCC, and PPP1r18 was correlated with tumor invasion depth, lymph node metastasis, distant metastasis, and reduced overall survival. We then observed that PPP1r18 overexpression enhanced cell proliferation in vitro and in vivo. Mechanistically, PPP1r18 regulated tumor progression of ESCC through activating the calcineurin-mediated ERK pathway, rather than binding to PPP1CA. Collectively, our results suggest that PPP1r18 promotes ESCC progression by regulating the calcineurin-mediated ERK pathway. PPP1r18 might be a potential target for the diagnosis and treatment of ESCC.

Keywords

ERK pathway; ESCC; PPP1r18; calcineurin; proliferation.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-50846
    99.10%, ERK1/2 Inhibitor
    ERK