2. Academic Validation
  3. Supramolecular Nanoparticles of Histone and Hyaluronic Acid for Co-Delivery of siRNA and Photosensitizer In Vitro

Supramolecular Nanoparticles of Histone and Hyaluronic Acid for Co-Delivery of siRNA and Photosensitizer In Vitro

  • Int J Mol Sci. 2024 May 16;25(10):5424. doi: 10.3390/ijms25105424.
Minxing Hu 1,  Jianwei Bao 1,  Yuanmei Zhang 1,  Lele Wang 1,  Ya Zhang 1,  Jiaxin Zhang 1,  Jihui Tang 1,  Qianli Zou 1 2
Affiliations

Affiliations

  • 1 Research and Industrialization of New Drug Release Technology Joint Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei 230032, China.
  • 2 Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei 230000, China.
PMID: 38791462 DOI: 10.3390/ijms25105424
Abstract

Small interfering RNA (siRNA) has significant potential as a treatment for Cancer by targeting specific genes or molecular pathways involved in Cancer development and progression. The addition of siRNA to Other therapeutic strategies, like photodynamic therapy (PDT), can enhance the Anticancer effects, providing synergistic benefits. Nevertheless, the effective delivery of siRNA into target cells remains an obstacle in Cancer therapy. Herein, supramolecular nanoparticles were fabricated via the co-assembly of natural histone and hyaluronic acid for the co-delivery of HMGB1-siRNA and the photosensitizer chlorin e6 (Ce6) into the MCF-7 cell. The produced siRNA-Ce6 nanoparticles (siRNA-Ce6 NPs) have a spherical morphology and exhibit uniform distribution. In vitro experiments demonstrate that the siRNA-Ce6 NPs display good biocompatibility, enhanced cellular uptake, and improved cytotoxicity. These outcomes indicate that the nanoparticles constructed by the co-assembly of histone and hyaluronic acid hold enormous promise as a means of siRNA and photosensitizer co-delivery towards synergetic therapy.

Keywords

histone; hyaluronic acid; photodynamic therapy; siRNA; supramolecular assembly.

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