2. Academic Validation
  3. Bestatin attenuates breast cancer stemness by targeting puromycin-sensitive aminopeptidase

Bestatin attenuates breast cancer stemness by targeting puromycin-sensitive aminopeptidase

  • Discov Oncol. 2024 May 30;15(1):197. doi: 10.1007/s12672-024-01063-4.
Yan Ma # 1,  Xintong Yang # 1,  Pengge Pan 1,  Jinyi Yang 1,  Xiaojuan Wu 2,  Danhan Wang 3,  Hui Gao 4
Affiliations

Affiliations

  • 1 Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, 750004, People's Republic of China.
  • 2 Shengzhou Food and Drug Testing Center, Shaoxing, 312400, China.
  • 3 The 2nd Afflicated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, 325035, People's Republic of China. handan3711@163.com.
  • 4 Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, 750004, People's Republic of China. gaohui@nxmu.edu.cn.
  • # Contributed equally.
PMID: 38814491 DOI: 10.1007/s12672-024-01063-4
Abstract

Breast Cancer is a prevalent malignant tumor among women with an increasing incidence rate annually. Breast Cancer Stem Cells (BCSCs) are integral in impeding tumor advancement and addressing drug resistance. Bestatin serves as an adjuvant chemotherapy, triggering Apoptosis in Cancer cells. In this study, the effects of bestatin on sorted BCSCs from breast Cancer cell lines have been studied. Our results indicated that bestatin inhibits the migration and proliferation of breast Cancer cells by reducing the stemness of BCSCs both in vitro and in vivo. Puromycin-sensitive Aminopeptidase is implicated in the process through the regulation of cell cycle, resulting in heightened cell Apoptosis and diminished cell proliferation of BCSCs. Our study suggest that targeting Cancer stem cell may offer a promising approach in breast Cancer treatment, presenting noval therapeutic strategies for patients with breast Cancer.

Keywords

Apoptosis; Bestatin; Breast cancer; Breast cancer stem cells; Proliferation; Puromycin-sensitive aminopeptidase.

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