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  2. FTO alleviated ferroptosis in septic cardiomyopathy via mediating the m6A modification of BACH1

FTO alleviated ferroptosis in septic cardiomyopathy via mediating the m6A modification of BACH1

  • Biochim Biophys Acta Mol Basis Dis. 2024 Jun 17:167307. doi: 10.1016/j.bbadis.2024.167307.
Hua Zeng 1 Junmei Xu 1 Rui Wu 1 Xin Wang 1 Yaqing Jiang 1 Qing Wang 1 Jiali Guo 1 Feng Xiao 2
Affiliations

Affiliations

  • 1 Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
  • 2 Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha 410011, China. Electronic address: xiaofengcsu@csu.edu.cn.
Abstract

Sepsis is a global health challenge that results in systemic inflammation, oxidative stress, and multi-organ dysfunction, with the heart being particularly susceptible. This study aimed to elucidate the effect of FTO, a key regulator in m6A methylation in septic cardiomyopathy, and its potential therapeutic implications. Cellular and animal models of septic myocardial injury were established. Moreover, it was revealed that Ferroptosis, which is a form of programmed necrosis occurring with iron dependence, was activated within cardiomyocytes during septic conditions. The overexpression of FTO-suppressed Ferroptosis alleviated heart inflammation and dysfunction and improved survival rates in vivo. However, the protective effects of FTO were attenuated by the overexpression of BACH1, which is a molecule negatively correlated with FTO. Mechanistically, FTO modulated the m6A modification of BACH1, suggesting a complex interplay in the regulation of cardiomyocyte damage and sepsis. Our findings reveal the potential of targeting the FTO/BACH1 axis and Ferroptosis inhibitors as therapeutic strategies for sepsis-induced cardiac injuries.

Keywords

BACH1; FTO; Ferroptosis; Septic cardiomyopathy; m(6)A methylation.

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