2. Academic Validation
  3. Blue light irradiation suppresses oral squamous cell carcinoma through induction of endoplasmic reticulum stress and mitochondrial dysfunction

Blue light irradiation suppresses oral squamous cell carcinoma through induction of endoplasmic reticulum stress and mitochondrial dysfunction

  • J Photochem Photobiol B. 2024 Jun 19:257:112963. doi: 10.1016/j.jphotobiol.2024.112963.
Hui Jiang 1,  Qiqi Fu 2,  Jiali Yang 2,  Haokuan Qin 1,  Angze Li 2,  Shangfeng Liu 3,  Muqing Liu 4
Affiliations

Affiliations

  • 1 Academy for Engineering and Technology, Fudan University, 220th Handan Road, Shanghai 200433, China.
  • 2 School of Information Science and Technology, Fudan University, 2005th Songhu Road, Shanghai 200433, China.
  • 3 Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, China. Electronic address: shangfeng_liu683@fudan.edu.cn.
  • 4 School of Information Science and Technology, Fudan University, 2005th Songhu Road, Shanghai 200433, China; Zhongshan DB-light Technology Co., Ltd, 14th Floor, South Wing, Shumao Building, Torch Development Zone, Zhongshan City, Guangdong Province 528437, China. Electronic address: mqliu@fudan.edu.cn.
PMID: 38908147 DOI: 10.1016/j.jphotobiol.2024.112963
Abstract

The therapeutic potential of blue LIGHT photobiomodulation in Cancer treatment, particularly in inhibiting cell proliferation and promoting cell death, has attracted significant interest. Oral squamous cell carcinoma (OSCC) is a prevalent form of oral Cancer, necessitating innovative treatment approaches to improve patient outcomes. In this study, we investigated the effects of 420 nm blue LED LIGHT on OSCC and explored the underlying mechanisms. Our results demonstrated that 420 nm blue LIGHT effectively reduced OSCC cell viability and migration, and induced G2/M arrest. Moreover, we observed that 420 nm blue LIGHT triggered endoplasmic reticulum (ER) stress and mitochondrial dysfunction in OSCC cells, leading to activation of the CHOP signal pathway and alterations in the levels of Bcl-2 and Bax proteins, ultimately promoting cell Apoptosis. Additionally, blue LIGHT suppressed mitochondrial gene expression, likely due to its damage to mitochondrial DNA. This study highlights the distinct impact of 420 nm blue LIGHT on OSCC cells, providing valuable insights into its potential application as a clinical treatment for oral Cancer.

Keywords

Apoptosis; Blue light; ER stress; Mitochondrial; Oral squamous cell carcinoma; Photobiomodulation.

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