2. Academic Validation
  3. Ginkgolide C attenuated Western diet-induced non-alcoholic fatty liver disease via increasing AMPK activation

Ginkgolide C attenuated Western diet-induced non-alcoholic fatty liver disease via increasing AMPK activation

  • Inflammation. 2024 Jul 1. doi: 10.1007/s10753-024-02086-3.
Yao Xie # 1,  Leyi Wei # 2,  Jiashi Guo # 1,  Qingsong Jiang 1,  Yang Xiang 1,  Yan Lin 1,  Huang Xie 1,  Xinru Yin 3,  Xia Gong 4,  Jingyuan Wan 5
Affiliations

Affiliations

  • 1 Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Department of Pharmacology, Chongqing Medical University, Chongqing, China.
  • 2 Department of Anatomy, Chongqing Medical University, Chongqing, China.
  • 3 Department of Gastroenterology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
  • 4 Department of Anatomy, Chongqing Medical University, Chongqing, China. xiagong@cqmu.edu.cn.
  • 5 Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Department of Pharmacology, Chongqing Medical University, Chongqing, China. jywan@cqmu.edu.cn.
  • # Contributed equally.
PMID: 38954260 DOI: 10.1007/s10753-024-02086-3
Abstract

Background: Non-alcoholic steatohepatitis (NASH) is a metabolic dysregulation-related disorder that is generally characterized by lipid metabolism dysfunction and an excessive inflammatory response. Currently, there are no authorized pharmacological interventions specifically designed to manage NASH. It has been reported that Ginkgolide C exhibits anti-inflammatory effects and modulates lipid metabolism. However, the impact and function of Ginkgolide C in diet-induced NASH are unclear.

Methods: In this study, mice were induced by a Western Diet (WD) with different doses of Ginkgolide C with or without Compound C (adenosine 5 '-monophosphate (AMP)-activated protein kinase (AMPK) inhibitor). The effects of Ginkgolide C were evaluated by assessing liver damage, steatosis, fibrosis, and AMPK expression.

Results: The results showed that Ginkgolide C significantly alleviated liver damage, steatosis, and fibrosis in the WD-induced mice. In addition, Ginkgolide C markedly improved Insulin resistance and attenuated hepatic inflammation. Importantly, Ginkgolide C exerted protective effects by activating the AMPK signaling pathway, which was reversed by AMPK inhibition.

Conclusion: Ginkgolide C alleviated NASH induced by WD in mice, potentially via activating the AMPK signaling pathway.

Keywords

AMPK; Compound C; Ginkgolide C; Non-alcoholic; steatohepatitis.

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