2. Academic Validation
  3. Multi-omics integration identifies ferroptosis involved in black phosphorus quantum dots-induced renal injury

Multi-omics integration identifies ferroptosis involved in black phosphorus quantum dots-induced renal injury

  • Sci Total Environ. 2024 Jul 5:947:174532. doi: 10.1016/j.scitotenv.2024.174532.
Fengkai Ruan 1,  Changqian Liu 2,  Jie Zeng 3,  Fucong Zhang 3,  Yu Jiang 4,  Zhenghong Zuo 5,  Chengyong He 6
Affiliations

Affiliations

  • 1 State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Department of Endocrinology, Xiang'an Hospital of Xiamen University, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China; Department of Thoracic Surgery, Xiang'an Hospital of Xiamen University, Xiamen 361102, China. Electronic address: 1489394097@qq.com.
  • 2 State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Department of Endocrinology, Xiang'an Hospital of Xiamen University, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: liuchangqian02@163.com.
  • 3 State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Department of Endocrinology, Xiang'an Hospital of Xiamen University, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.
  • 4 Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian 361003, China; Molecular Diagnostic Laboratory for Precision Medicine, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361000, China.
  • 5 State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Department of Endocrinology, Xiang'an Hospital of Xiamen University, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: zuozhenghong@xmu.edu.cn.
  • 6 State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Department of Endocrinology, Xiang'an Hospital of Xiamen University, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: hecy@xmu.edu.cn.
PMID: 38972417 DOI: 10.1016/j.scitotenv.2024.174532
Abstract

Black phosphorus quantum dots (BPQDs) have recently emerged as a highly promising contender in biomedical applications ranging from drug delivery systems to Cancer therapy modalities. Nevertheless, the potential toxicity and its effects on human health need to be thoroughly investigated. In this study, we utilized multi-omics integrated approaches to explore the complex mechanisms of BPQDs-induced kidney injury. First, histological examination showed severe kidney injury in male mice after subacute exposure to 1 mg/kg BPQDs for 28 days. Subsequently, transcriptomic and metabolomic analyses of kidney tissues exposed to BPQDs identified differentially expressed genes and metabolites associated with Ferroptosis, an emerging facet of regulated cell death. Our findings highlight the utility of the multi-omics integrated approach in predicting and elucidating potential toxicological outcomes of nanomaterials. Furthermore, our study provides a comprehensive understanding of the mechanisms driving BPQDs-induced kidney injury, underscoring the importance of recognizing Ferroptosis as a potential toxic mechanism associated with BPQDs.

Keywords

Black phosphorus quantum dots; Ferroptosis; Kidney injury; Multi-omics analysis.

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