2. Academic Validation
  3. Neutrophil-derived migrasomes are an essential part of the coagulation system

Neutrophil-derived migrasomes are an essential part of the coagulation system

  • Nat Cell Biol. 2024 Jul;26(7):1110-1123. doi: 10.1038/s41556-024-01440-9.
Dong Jiang 1,  Lin Jiao 2,  Qing Li 3,  Renxiang Xie 1,  Haohao Jia 1,  ShiHui Wang 4,  Yining Chen 1,  Siyuan Liu 1,  Dandan Huang 1,  Jiajia Zheng 5,  Wenhao Song 1,  Ying Li 1,  JianFeng Chen 4,  Jinsong Li 3,  Binwu Ying 2,  Li Yu 6
Affiliations

Affiliations

  • 1 State Key Laboratory of Membrane Biology, Tsinghua University-Peking University Joint Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, China.
  • 2 Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
  • 3 Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.
  • 4 State Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.
  • 5 Department of Laboratory Medicine, Peking University Third Hospital, Beijing, People's Republic of China.
  • 6 State Key Laboratory of Membrane Biology, Tsinghua University-Peking University Joint Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing, China. liyulab@mail.tsinghua.edu.cn.
PMID: 38997457 DOI: 10.1038/s41556-024-01440-9
Abstract

Migrasomes are organelles that are generated by migrating cells. Here we report the key role of neutrophil-derived migrasomes in haemostasis. We found that a large number of neutrophil-derived migrasomes exist in the blood of mice and humans. Compared with neutrophil cell bodies and platelets, these migrasomes adsorb and enrich coagulation factors on the surface. Moreover, they are highly enriched with adhesion molecules, which enable them to preferentially accumulate at sites of injury, where they trigger platelet activation and clot formation. Depletion of neutrophils, or genetic reduction of the number of these migrasomes, significantly decreases platelet plug formation and impairs coagulation. These defects can be rescued by intravenous injection of purified neutrophil-derived migrasomes. Our study reveals neutrophil-derived migrasomes as a previously unrecognized essential component of the haemostasis system, which may shed LIGHT on the cause of various coagulation disorders and open therapeutic possibilities.

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