2. Academic Validation
  3. Copper-loaded Milk-Protein Derived Microgel Preserves Cardiac Metabolic Homeostasis After Myocardial Infarction

Copper-loaded Milk-Protein Derived Microgel Preserves Cardiac Metabolic Homeostasis After Myocardial Infarction

  • Adv Sci (Weinh). 2024 Jul 15:e2401527. doi: 10.1002/advs.202401527.
Xiaoqian Hong 1 2,  Geer Tian 1 2 3,  Binyao Dai 4,  Xuhao Zhou 1 2,  Ying Gao 1 2,  Lianlian Zhu 1 2,  Haoran Liu 5,  Qinchao Zhu 6,  Liwen Zhang 4,  Yang Zhu 2 3 4,  Daxi Ren 6,  Chengchen Guo 5,  Jinliang Nan 1 2,  Xianbao Liu 1 2,  Jian'an Wang 1 2,  Tanchen Ren 1 2
Affiliations

Affiliations

  • 1 Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China.
  • 2 State Key Laboratory of Transvascular Implantation Devices, Heart Regeneration and Repair Key Laboratory Zhejiang Province, Hangzhou, 310009, China.
  • 3 Binjiang Institute of Zhejiang University, Hangzhou, 310053, China.
  • 4 MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.
  • 5 School of Engineering, Westlake University, Hangzhou, 310023, China.
  • 6 Institute of Dairy Science, College of Animal Sciences, Zhejiang University, Hangzhou, 310027, China.
PMID: 39007192 DOI: 10.1002/advs.202401527
Abstract

Myocardial Infarction (MI) is a leading cause of death worldwide. Metabolic modulation is a promising therapeutic approach to prevent adverse remodeling after MI. However, whether material-derived cues can treat MI through metabolic regulation is mainly unexplored. Herein, a Cu2+ loaded casein microgel (CuCMG) aiming to rescue the pathological intramyocardial metabolism for MI amelioration is developed. Cu2+ is an important ion factor involved in metabolic pathways, and intracardiac copper drain is observed after MI. It is thus speculated that intramyocardial supplementation of Cu2+ can rescue myocardial metabolism. Casein, a milk-derived protein, is screened out as Cu2+ carrier through molecular-docking based on Cu2+ loading capacity and accessibility. CuCMGs notably attenuate MI-induced cardiac dysfunction and maladaptive remodeling, accompanied by increased angiogenesis. The results from unbiased transcriptome profiling and Oxidative Phosphorylation analyses support the hypothesis that CuCMG prominently rescued the metabolic homeostasis of myocardium after MI. These findings enhance the understanding of the design and application of metabolic-modulating biomaterials for ischemic cardiomyopathy therapy.

Keywords

casein; copper; hydrogels; metabolic homeostasis; myocardial infarctions.

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  • HY-15534
    99.0%, Mitochondrial Membrane Potential Probe