2. Academic Validation
  3. Wireless Optogenetic Targeting Nociceptors Helps Host Cells Win the Competitive Colonization in Implant-Associated Infections

Wireless Optogenetic Targeting Nociceptors Helps Host Cells Win the Competitive Colonization in Implant-Associated Infections

  • Small Methods. 2024 Aug 1:e2400216. doi: 10.1002/smtd.202400216.
Xinyu Fang 1 2 3,  Haiqi Ding 1 2 3,  Yang Chen 1 2 3,  Qijin Wang 1 2 3 4,  Xuhui Yuan 1 2 3,  Chaofan Zhang 1 2 3,  Jiagu Huang 5,  Jiexin Huang 6,  Jianhua Lv 7,  Hongxin Hu 7,  Changyu Huang 8,  Xueni Hu 9 10,  Yiming Lin 1 2 3,  Nanxin Zhang 1 2 3,  Wei Zhou 1 2 3,  Ying Huang 1 2 3,  Wenbo Li 1 2 3,  Susheng Niu 11,  Zhaoyang Wu 1 2 3,  Jianhua Lin 1 2 3,  Bin Yang 9 10,  Tifei Yuan 12,  Wenming Zhang 1 2 3
Affiliations

Affiliations

  • 1 Department of Orthopedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
  • 2 Department of Orthopedic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350000, China.
  • 3 Fujian Provincial Institute of Orthopedics, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
  • 4 Department of Orthopedics, Affiliated Mindong Hospital of Fujian Medical University, Fu'an, 355000, China.
  • 5 Department of Orthopedic Surgery, Ningde municipal Hospital, Ningde, 352000, China.
  • 6 Department of Orthopedic Surgery, Nanping First Hospital, Nanping, 353000, China.
  • 7 Department of Orthopedic Surgery, Affiliated Hospital of Putian University, Putian, 351100, China.
  • 8 Department of Orthopedic Surgery, Quanzhou Orthopedic-traumatological Hospital, Quanzhou, 362000, China.
  • 9 Department of Laboratory Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350000, China.
  • 10 Department of Laboratory Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350000, China.
  • 11 Key Laboratory of Orthopedics & Traumatology of Traditional Chinese Medicine and Rehabilitation Ministry of Education, Fujian university of Traditional Chinese Medicine, Fuzhou, 350000, China.
  • 12 Shanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, 200000, China.
PMID: 39087367 DOI: 10.1002/smtd.202400216
Abstract

The role of nociceptive nerves in modulating immune responses to harmful stimuli via pain or itch induction remains controversial. Compared to conventional surgery, various implant surgeries are more prone to infections even with low Bacterial loads. In this study, an optogenetic technique is introduced for selectively activating peripheral nociceptive nerves using a fully implantable, wirelessly rechargeable optogenetic device. By targeting nociceptors in the limbs of awake, freely moving mice, it is found that activation induces anticipatory immunity in the innervated territory and enhances the adhesion of various host cells to the implant surface. This effect mediates acute immune cell-mediated killing of Staphylococcus aureus on implants and enables the host to win "implant surface competition" against Staphylococcus aureus. This finding provides new strategies for preventing and treating implant-associated infections.

Keywords

anticipatory immunity; implant surface competition; implant‐associated infections; nociceptors; optogenetics.

Figures
Products